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Št. zadetkov: 2
Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domain
Mujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašić, Marko Anderluh, Žiga Jakopin
Izvirni znanstveni članek
Oznake: Galectin-8N;d-galactal;benzimidazole;selectivity;X-ray crystallography;cytokine secretion;
Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d- ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Benzimidazole-galactosides bind selectively to the galectin-8 N-terminal domain
Mujtaba Hassan, Sjors van Klaveren, Maria Håkansson, Carl Diehl, Rebeka Kovačič, Floriane Baussière, Anders Sundin, Jaka Dernovšek, Marko Anderluh, Tihomir Tomašić, Žiga Jakopin
Izvirni znanstveni članek
Oznake: benzimidazole;galectin-8N;quinoline;selectivity;molecular dynamics;x-ray crystallography;
We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline-galactoside ligand at a resolution of 1.6Å. Based on this X-ray structure, a collection of galactosides derivatised at O3 with triazole, benzimidazole, benzothiazole, a ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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