Št. zadetkov: 10
Izvirni znanstveni članek
Oznake:
rak jajčnikov;serozni karcinom jajčnikov visoke stopnje;HIO-80;ovarian cancer;high-grade serous ovarian carcinoma;
Ovarian cancer (OC) is highly lethal and heterogeneous. Several hormones are involved in OC etiology including estrogens; however, their role in OC is not completely understood. Here, we performed targeted transcriptomics and estrogen metabolism analyses in high-grade serous OC (HGSOC), OVSAHO, Kura ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
navadna ajda;nizkotemperaturna plazma;kalivost semen;viabilnost semen;privzem vode;
Nizkotemperaturna plazma ima širok potencial za uporabo v živilski tehnologiji in nekonvencionalnem kmetijstvu, saj naj bi vzpodbujala kalitev in zgodnjo rast sadik, povečala pridelek ter mikrobno inaktivirala površino semen. Navadna ajda (Fagopyrum esculentum) vsebuje veliko kvalitetnih proteinov i ...
Leto:
2020
Vir:
Biotehniška fakulteta (UL BF)
Pregledni znanstveni članek
Oznake:
rak jajčnikov;estrogeni;imunosupresivno mikrookolje;ovarian cancer;estrogens;immunosuppressive microenvironment;
Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the context-dependent constituents of the-by the time of diagnosis- ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
endocrinology;endometrial cancer;androgen hormones;
Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving muta- tional landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our kno ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
androgen hormones;endometriosis sub-phenotypes;ovarian neoplasms;two-sample Mendelian randomization;
Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases rema ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
liquid chromatography-tandem mass spectrometry;androgens;progestogens;mineralocorticoids;glucocorticoids;11-oxygenenated steroids;
Mass spectrometric-based steroidomics is a valuable analytical approach that gives a comprehensive understanding of the interlinked steroid biosynthetic pathways. Here, we describe a rapid and versatile liquid chromatography-tandem mass spectrometry (LC-MS/MS) method designed to accurately quantify ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
androgens;estrogens;intracrinology;sulfatase;sulfotransferase;
Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the reverse reaction and require 3-phosphoadenosin ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
endometrial cancer;11-oxyandrogens;intracrinology;androgen receptor;LC-MS/MS profiling;
Background: Endometrial cancer (EC) is a prevalent gynecological malignancy globally, with a rising incidence trend. While classic androgens have been implicated with EC risk, the role of their 11-oxygenated metabolites is poorly understood. Here, we studied 11-oxyandrogen formation from steroid pre ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
endometrial cancer;ovarian cancer;estrogen formation;
Endometrial (EC) and ovarian (OC) cancers are generally considered as post-menopausal, hormone-dependent pathologies with increasing incidence and mortality rate. Estrogen intracrine action is regarded vital in the cancer initiation and progression. Estrogens can form locally from androgen and estro ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
high-grade serous ovarian cancer;estrogen metabolisem;prognostic biomarkers;therapeutic targets;transcriptomic analysis;
The high mortality rate due to chemoresistance in patients with high-grade ovarian cancer (HGSOC) emphasizes the urgent need to determine optimal treatment strategies for advanced and recurrent cases. Our study investigates the interplay between estrogens and chemoresistance in HGSOC and shows clear ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)