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Št. zadetkov: 7
Model cell lines and tissues of different HGSOC subtypes differ in local estrogen biosynthesis
Renata Pavlič, Marija Gjorgoska, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: rak jajčnikov;serozni karcinom jajčnikov visoke stopnje;HIO-80;ovarian cancer;high-grade serous ovarian carcinoma;
Ovarian cancer (OC) is highly lethal and heterogeneous. Several hormones are involved in OC etiology including estrogens; however, their role in OC is not completely understood. Here, we performed targeted transcriptomics and estrogen metabolism analyses in high-grade serous OC (HGSOC), OVSAHO, Kura ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Vpliv nizkotemperaturne plazme na privzem vode, viabilnost in kalivost ajde (Fagopyrum esculentum)
Marija Gjorgoska, Nada Gvozdenović, Nika Šijanec, Hana Trček, Zala Vidic
Izvirni znanstveni članek
Oznake: navadna ajda;nizkotemperaturna plazma;kalivost semen;viabilnost semen;privzem vode;
Nizkotemperaturna plazma ima širok potencial za uporabo v živilski tehnologiji in nekonvencionalnem kmetijstvu, saj naj bi vzpodbujala kalitev in zgodnjo rast sadik, povečala pridelek ter mikrobno inaktivirala površino semen. Navadna ajda (Fagopyrum esculentum) vsebuje veliko kvalitetnih proteinov i ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Estrogens and the Schrödinger's cat in the ovarian tumor microenvironment
Marija Gjorgoska, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Pregledni znanstveni članek
Oznake: rak jajčnikov;estrogeni;imunosupresivno mikrookolje;ovarian cancer;estrogens;immunosuppressive microenvironment;
Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the context-dependent constituents of the-by the time of diagnosis- ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Integration of androgen hormones in endometrial cancer biology
Marija Gjorgoska, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Pregledni znanstveni članek
Oznake: endocrinology;endometrial cancer;androgen hormones;
Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving muta- tional landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our kno ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
ǂThe ǂeffect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms
Marija Gjorgoska, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: androgen hormones;endometriosis sub-phenotypes;ovarian neoplasms;two-sample Mendelian randomization;
Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases rema ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Simultaneous measurement of 17 endogenous steroid hormones in human serum by liquid chromatography-tandem mass spectrometry without derivatization
Marija Gjorgoska, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: liquid chromatography-tandem mass spectrometry;androgens;progestogens;mineralocorticoids;glucocorticoids;11-oxygenenated steroids;
Mass spectrometric-based steroidomics is a valuable analytical approach that gives a comprehensive understanding of the interlinked steroid biosynthetic pathways. Here, we describe a rapid and versatile liquid chromatography-tandem mass spectrometry (LC-MS/MS) method designed to accurately quantify ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Synthesis of estrogens in cell lines of endometrial and ovarian cancer
Marija Gjorgoska, Tea Lanišnik-Rižner, Maša Sinreih, Petra Golja, Petra Golja, Rok Kostanjšek
Magistrsko delo
Oznake: endometrial cancer;ovarian cancer;estrogen formation;
Endometrial (EC) and ovarian (OC) cancers are generally considered as post-menopausal, hormone-dependent pathologies with increasing incidence and mortality rate. Estrogen intracrine action is regarded vital in the cancer initiation and progression. Estrogens can form locally from androgen and estro ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 7
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