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Št. zadetkov: 2
New class of Hsp90 C-terminal domain inhibitors with anti-tumor properties against triple-negative breast cancer
Živa Zajec, Jaka Dernovšek, Jernej Cingl, Iza Ogris, Marius Gedgaudas, Asta Zubrienė, Ana Mitrović, Simona Golič Grdadolnik, Martina Gobec, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: analize;zaviralci;fenili;rak dojk;
Triple-negative breast cancer (TNBC) remains a treatment challenge and requires innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has emerged as a promising therapeutic target. In this study, we present the optimization of the Hsp90 C-terminal domain (CTD) inhibi ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Hiding in plain sight
Jaka Dernovšek, Tjaša Goričan, Marius Gedgaudas, Živa Zajec, Dunja Urbančič, Ana Jug, Žiga Skok, Simona Golič Grdadolnik, Janez Ilaš, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Hsp90;isoform selectivity;topoisomerase II;
Due to their impact on several oncogenic client proteins, the Hsp90 family of chaperones has been widely studied for the development of potential anticancer agents. Although several Hsp90 inhibitors have entered clinical trials, most were unsuccessful because they induced a heat shock response (HSR) ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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