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Št. zadetkov: 6
Proteomska identifikacija substratov cisteinskih katepsinov na površini rakavih celic
Marko Fonović
Video in druga učna gradiva
Oznake: biology
Proteaze so encimi, ki cepijo peptidno vez in imajo pomembno vlogo tudi pri zunajcelični signalizaciji in preoblikovanju zunajceličnega matriksa. S svojim delovanjem lahko proteine na celični membrani aktivirajo, inaktivirajo ali pa kako drugače vplivajo na njihovo funkcionalnost. Cisteinski katepsi ...
Leto: 2016 Vir: videolectures.net
Odlični v znanosti 2016 - Naravoslovje 2. del
Nataša Ivanuš Čuček , József Györkös , Mihael Brenčič , Jernej Polajnar , Mojca Kerec Kos , Marko Fonović
Video in druga učna gradiva
Oznake: biology;chemistry
**prof. dr. Marko Fonović: Proteomska identifikacija substratov cisteinskih katepsinov na površini rakavih celic**\\ Proteaze so encimi, ki cepijo peptidno vez in imajo pomembno vlogo tudi pri zunajcelični signalizaciji in preoblikovanju zunajceličnega matriksa. S svojim delovanjem lahko proteine n ...
Leto: 2016 Vir: videolectures.net
Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer
Marija Grozdanić, Barbara Sobotič, Monika Biasizzo, Tilen Sever, Robert Vidmar, Matej Vizovišek, Boris Turk, Marko Fonović
Izvirni znanstveni članek
Oznake: cancer;cysteine cathepsin;cathepsin L;EGFR;extracellular cleavage;resistance to TKIs;
Proteolytic activity in the tumour microenvironment is an important factor in cancer development since it can also affect intracellular signalling pathways via positive feedback loops that result in either increased tumour growth or resistance to anticancer mechanisms. In this study, we demonstrated ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea
Katarina Karničar, Igor Drobnak, Marko Petek, Vasilka Magdevska, Jaka Horvat, Robert Vidmar, Špela Baebler, Ana Rotter, Polona Jamnik, Štefan Fujs, Boris Turk, Marko Fonović, Kristina Gruden, Gregor Kosec, Hrvoje Petković
Izvirni znanstveni članek
Oznake: aktinomicete;Saccharopolyspora erythraea;sekundarni metaboliti;antibiotiki;eritromicin;biosinteza;metabolno inženirstvo;proteomika;
Background Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-pr ...
Leto: 2016 Vir: Nacionalni inštitut za biologijo (NIB)
Mechanistic insights into CrCEP1
Katarina Petra van Midden, Melissa Mantz, Marko Fonović, Martin Gazvoda, Jurij Svete, Pitter F. Huesgen, Renier A. L. van der Hoorn, Marina Klemenčič
Izvirni znanstveni članek
Oznake: proteoliza;sonde na osnovi aktivnosti;papainu podobna cisteinska proteaza;transpeptidacija;zelene alge;proteolysis;activity-based probes;papain-like cysteine protease;transpeptidation;green algae;
Proteases, essential regulators of plant stress responses, remain enigmatic in their precise functional roles. By employing activity-based probes for real-time monitoring, this study aimed to delve into protease activities in Chlamydomonas reinhardtii exposed to oxidative stress induced by hydrogen ...
Leto: 2024 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea
Benjamin Kirm, Vasilka Magdevska, Miha Tome, Marinka Horvat, Katarina Karničar, Marko Petek, Robert Vidmar, Špela Baebler, Polona Jamnik, Štefan Fujs, Jaka Horvat, Marko Fonović, Boris Turk, Kristina Gruden, Hrvoje Petković, Gregor Kosec
Izvirni znanstveni članek
Oznake: aktinomicete;sekundarni metaboliti;eritromicin;regulacija biosinteze;molekularna genetika;erythromycin;polyketide;regulator;SACE_5599;lmbU;differentiation (biology);sporulation;strain improvement;metabolic engineering;
Background Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. Genes encoding erythromycin biosynthesis are organized in a gene cluster, spanning over 60 kbp of DNA. Most often, gene clusters encoding biosynthesis of secondary metabolite ...
Leto: 2013 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 6
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