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Št. zadetkov: 9
Vloga cistatina F in cisteinskih katepsinov pri delovanju citotoksičnih limfocitov T
Mateja Prunk, Janko Kos
Doktorska disertacija
Oznake: biomedicina;klinična biokemija;imunski sistem;molekularna imunologija;citotoksični limfociti T;naravne celice ubijalke;citotoksičnost;perforin;grancim;cisteinski katepsini;katepsin C;katepsin H;katepsin L;cistatini;cistatin F;doktorske disertacije;
Citotoksični limfociti T CD8+ (CTL) in naravne celice ubijalke (celice NK) imajo ključno vlogo v imunskem odzivu proti celicam, okuženim z virusi in proti rakavim celicam, saj jih lahko neposredno ubijejo. CTL in celice NK se bistveno razlikujejo v načinih aktivacije, vendar pa so molekularni mehani ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Pomen določanja galektina-3 v serumu pri osteoporozi in osteoartrozi
Mateja Prunk, Janja Marc, Jerka Dumić
Magistrsko delo
Oznake: osteoartroza;galektin-3;statistične metode;mineralna kostna gostota;biokemijski kazalci;kostna premena;metoda ELISA;
Pomen določanja galektina-3 v serumu pri osteoporozi in osteoartrozi
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
Cathepsin X activity does not affect NK-target cell synapse but Is rather distributed to cytotoxic granules
Tanja Jakoš, Mateja Prunk, Anja Pišlar, Janko Kos
Izvirni znanstveni članek
Oznake: citotoksične celice;katepsin X;imunološka sinapsa;cytotoxic cells;cathepsin X;NK-92;immunological synapse;LFA-1;
Cathepsin X is a lysosomal peptidase that is involved in tumour progression and represents a potential target for therapeutic interventions. In addition, it regulates important functions of immune cells and is implicated in the modulation of tumour cell–immune cell crosstalk. Selective cathepsin X i ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells
Mateja Prunk, Milica Perišić, Jerica Sabotič, Urban Švajger, Janko Kos
Izvirni znanstveni članek
Oznake: cystatin F;cysteine cathepsins;TALL-104;
Leto: 2019 Vir: Onkološki inštitut Ljubljana (OI)
Extracellular cystatin F is internalised by cytotoxic T lymphocytes and decreases their cytotoxicity
Mateja Prunk, Milica Perišić, Tanja Jakoš, Jerica Sabotič, Urban Švajger, Janko Kos
Izvirni znanstveni članek
Oznake: cystatin F;cathepsins;cytotoxic lymphocytes;
Cystatin F is a protein inhibitor of cysteine cathepsins, peptidases involved in the activation of the effector molecules of the perforin/granzyme pathway. Cystatin F was previously shown to regulate natural killer cell cytotoxicity. Here, we show that extracellular cystatin F has a role in regulati ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
ǂThe ǂfungal Clitocybe nebularis lectin binds distinct cell surface glycoprotein receptors to induce cell death selectively in Jurkat cells
Milica Perišić, Simon Žurga, Špela Konjar, Mateja Prunk, Janko Kos, Jerica Sabotič
Izvirni znanstveni članek
Oznake:
The fungal Clitocybe nebularis lectin binds distinct cell surface glycoprotein receptors to induce cell death selectively in Jurkat cells
Leto: 2022 Vir: Institut Jožef Stefan (IJS)
New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity
Ana Mitrović, Emanuela Senjor, Marko Jukič, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić, Stanislav Gobec, Janko Kos
Izvirni znanstveni članek
Oznake: cathepsin V;small-molecule inhibitors;antitumor therapy;cancer;cystatin F;
Cathepsin V is a human lysosomal cysteine peptidase with specific functions during pathological processes and is as such a promising therapeutic target. Peptidase inhibitors represent powerful pharmacological tools for regulating excessive proteolytic activity in various diseases. Cathepsin V is hig ...
Leto: 2022 Vir: Institut Jožef Stefan (IJS)
Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Emanuela Senjor, Martina Pirro, Urban Švajger, Mateja Prunk, Jerica Sabotič, Anahid Jewett, Paul J. Hensbergen, Milica Perišić, Janko Kos
Izvirni znanstveni članek
Oznake: cystatin F;immunosuppression;NK cells;N-Glycosylation;
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non-functional NK cell stage, called split-anergy. We show that N-glycosylation determines the localization and cellular function ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Evaluation of corticophobia in patients with atopic dermatitis and psoriasis using the TOPICOP© score
Mateja Starbek Zorko, Maja Benko, Mateja Zemljič, Tanja Prunk, Tanja Prunk
Izvirni znanstveni članek
Oznake: atopic dermatitis;psoriasis;corticosteroids;corticophobia;compliance;
Introduction: Atopic dermatitis (AD) and psoriasis (PS) are skin diseases that have a significant impact on the quality of life. The correct application of corticosteroids in topical treatment is highly effective and safe for patients. Excessive and irrational fear of these drugs based on incorrect ...
Leto: 2023 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 9
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