Št. zadetkov: 14
Diplomsko delo
Oznake:
diplomska dela;geografske diplome;Slovenija;družbena geografija;migracije;šport;
Geografske značilnosti selitev slovenskih športnikov in športnih delavcev
Leto:
2013
Vir:
Filozofska fakulteta (UL FF)
Magistrsko delo
Oznake:
butirilholinesteraza;z mitogenom aktivirane protein kinaze p38α;Alzheimerjeva bolezen;računalniško načrtovanje;virtualno rešetanje;
Pri magistrski nalogi smo računalniško načrtovali dualne zaviralce butirilholinesteraze in z mitogenom aktivirane protein kinaze p38α za zdravljenje Alzheimerjeve bolezni. Ta bolezen je pereč problem v razvitih državah, kjer se daljša življenjska doba. Trenutno zdravljenje poteka z zaviralci acetilh ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake:
edox;covalent;screening;hits;PAINS;assays;
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. He ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
imunopreoteasom;zaviralci;psoralen;immunoproteasome;psoralen core;non-peptidic;electrophilic compounds;warhead scan;
The immunoproteasome is a multicatalytic protease that is predominantly expressed in cells of hematopoietic origin. Its elevated expression has been associated with autoimmune diseases, various types of cancer, and inflammatory diseases. Selective inhibition of its catalytic activities is therefore ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
immunoproteasome;covalent inhibitor;virtual screening;beta5i selective inhibitor;
Large-scale virtual screening of boronic acid derivatives was performed to identify nonpeptidic covalent inhibitors of the %5i subunit of the immunoproteasome. A hierarchical virtual screening cascade including noncovalent and covalent docking steps was applied to a virtual library of over 104,000 c ...
Leto:
2019
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
immunoproteasome;benzoxazole-2-carbonitriles;bidentate covalent inhibitors;fragments;non-covalent recognition;
Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, including inflammation, autoimmune diseases, and hematolo ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
antibacterial agents;DNA-encoded library;screening;inhibitors;
Screening of DNA-encoded libraries is an emerging technology for discovering hits against protein targets. With the recent launch of the DELopen platform, a facile screening of 4.4 billion compounds is available to accelerate the drug discovery process. Here we report an affinity-based screening of ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
fragment-based drug discovery;hit triage;inhibitors;antibacterial agents;
Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general a ...
Leto:
2023
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
viscosity;protein formulations;biopharmaceuticals;viscosity-reducing agents;computational screening;
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
thiazoles;hit profiling;promiscuous compounds;frequent hitters;privileged scaffolds;fragments;
Thiazoles exhibit a wide range of biological activities and therefore represent useful and attractive building blocks. To evaluate their usefulness and pinpoint their liabilities in fragment screening campaigns, we assembled a focused library of 49 fragment-sized thiazoles and thiadiazoles with vari ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)