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Št. zadetkov: 6
Analysis and prediction of aggregation and degradation in protein-based biopharmaceuticals
Mitja Zidar, Miha Ravnik
Doktorska disertacija
Oznake: soft matter physics;biophysics;proteins;biopharmaceuticals;monoclonal antibodies;aggregation;degradation;viscosity;
Research in protein aggregation and other degradation routes is of major importance in recent years, influencing the quality and consistency of biopharmaceutical drugs used to treat various life-threatening conditions. In this work we study the open soft-matter physics questions behind such processe ...
Leto: 2020 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Določanje mehanizmov agregacije monoklonskih protiteles v bioloških zdravilih
Mitja Zidar, Miha Ravnik, Drago Kuzman
Magistrsko delo
Oznake: biofizika;proteini;monoklonska protitelesa;agregacija;koloidna stabilnost;konformacijska stabilnost;diferencialna kalorimetrija;gelska izključitvena kromatografija;dinamično sipanje svetlobe;
Določanje mehanizmov agregacije monoklonskih protiteles v bioloških zdravilih
Leto: 2016 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Fizikalna optimizacija procesov čiščenja bioloških zdravil
Maša Lah, Miha Ravnik, Mitja Zidar
Magistrsko delo
Oznake: biofizika;proteini;agregacija;biološka zdravila;monoklonska protitelesa;gelska izključitvena kromatografija;fluorescenčna spektroskopija;intrinzična proteinska fluorescenca;
Delo obravnava fizikalno optimizacijo pogojev za čiščenje proteinov in povezanih metod za iskanje optimalnih pogojev za minimizacijo agregacije. Metodološko delo temelji na kombinaciji eksperimentov in modelske analize eksperimentov, pri čemer sta glavni uporabljeni eksperimentalni metodi gelska izk ...
Leto: 2022 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability
Blaž Lebar, Mitja Zidar, Janez Mravljak, Roman Šink, Aleš Žula, Stane Pajk
Izvirni znanstveni članek
Oznake: biopharmaceuticals;buffer;stress;aggregates;alternative buffers;stability;
The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer composition plays a pivotal role. However, conventional buffers l ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek, Goran Miličić, Aleš Žula, Stanislav Gobec
Izvirni znanstveni članek
Oznake: viscosity;protein formulations;biopharmaceuticals;viscosity-reducing agents;computational screening;
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Polysorbate stability
Blaž Lebar, Tinkara Lekić, Pija Košir, Miha Kastelic, Mitja Zidar, Janez Mravljak, Stane Pajk
Izvirni znanstveni članek
Oznake: polysorbates;primary packaging material;hydrolysis;stability;histidine;acetic acid;principal component analysis;
Polysorbates, widely used excipients in drug formulations, present a stability challenge due to complex degradation processes. This study investigates the hydrolysis of polysorbate (PS) under temperature stress (50 °C), focusing on the impact of primary packaging materials (glass vs. plastic vials), ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 6
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