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Št. zadetkov: 6
ǂA ǂsimple in silico approach to generate gene-expression profiles from subsets of cancer genomics data
Mohammed Khurshed, Remco J. Molenaar, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: cancer genomics;cBioPortal;data mining;epigenetics;gene expression;in silico;
In biomedical research, large-scale profiling of gene expression has become routine and offers a valuable means to evaluate changes in onset and progression of diseases, in particular cancer. An overwhelming amount of cancer genomics data has become publicly available, and the complexity of these da ...
Leto: 2019 Vir: Nacionalni inštitut za biologijo (NIB)
Comparison of different methodologies and cryostat versus paraffin sections for chromogenic immunohistochemistry
Vashendriya V. V. Hira, Annique Loncq de Jong, Klea Ferro, Mohammed Khurshed, Remco J. Molenaar, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: immunohistochemistry;chromogens;aminoethyl carbazole;AEC;3,3'-diaminobenzidine;DAB;antigen retrieval;tonsil;
Immunohistochemistry (IHC) specifically localizes proteins in cells and tissues, but methodologies vary widely. Therefore, we performed a methodological IHC optimization and validation study. First, we compared advantages and disadvantages of cryostat sections versus paraffin sections. Second, we co ...
Leto: 2019 Vir: Nacionalni inštitut za biologijo (NIB)
Hyperthermia as a potential cornerstone of effective multimodality treatment with radiotherapy, cisplatin and PARP inhibitor in IDH1-mutated cancer cells
Mohammed Khurshed, Elia Prades-Sagarra, Sarah Al Saleh, Peter Sminia, Johanna W Wilmink, Remco J. Molenaar, Hans Crezee, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: izocitrat dehidrogenaza;PARP;hipertemija;D‐2‐hidroksiglutarat;radioterapija;cisplatin;isocitrate dehydrogenase;hyperthermia;D‐2‐hydroxyglutarate;radiotherapy;
Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and progression of these types of cancer due to neomorph ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches
Barbara Breznik, Clara Limbäck-Stokin, Janko Kos, Mohammed Khurshed, Vashendriya V. V. Hira, Roman Bošnjak, Tamara Lah Turnšek, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: cysteine cathepsins;glioblastoma stem cells;niches;stroma;proteolytic activity;
Glioblastoma (GBM) is the most lethal brain tumor also due to malignant and therapy-resistant GBM stem cells (GSCs) that are localized in protecting hypoxic GSC niches. Some members of the cysteine cathepsin family of proteases have been found to be upregulated in GBM. Cathepsin K gene expression is ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Mohammed Khurshed, Niels Aarnoudse, Renske Hulsbos, Vashendriya V. V. Hira, Hanneke WM van Laarhoven, Johanna W Wilmink, Remco J. Molenaar, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: izocitrat dehidrogenaza;kemosenzibilnost;cis-diamminedichloroplatinum;2-hidroksiglutarat;isocitrate dehydrogenase;chemosensitivity;2-hydroxyglutarate;
Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1MUT) enzymes consume NADPH to produce D-2-hydroxyglutarate (D-2HG) resulting ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
ǂA ǂphase Ib clinical trial of metformin and chloroquine in patients with IDH1-mutated solid tumors
Mohammed Khurshed, Remco J. Molenaar, Myra E van Linde, Ron Mathôt, Eduard A. Struys, Tom van Wezel, Cornelis J. F. van Noorden, Heinz-Josef Klümpen, Judith V. M. G. Bovée, Johanna W Wilmink
Izvirni znanstveni članek
Oznake: metformin;chloroquine;cancer;isocitrate dehydrogenase;pharmacokinetics;glioblastoma;intrahepatic cholangiocarcinoma;chondrosarcoma;
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) occur in 60% of chondrosarcoma, 80% of WHO grade II-IV glioma and 20% of intrahepatic cholangiocarcinoma. These solid IDH1-mutated tumors produce the oncometabolite D-2-hydroxyglutarate (D-2HG) and are more vulnerable to disruption of their ...
Leto: 2021 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 6
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