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Št. zadetkov: 5
Suitability and reliability of in vitro epithelial cell models for nasal and pulmonary drug permeability determination
Nadica Sibinovska, Katja Kristan, Simon Žakelj
Doktorska disertacija
Oznake:
Uporaba ustreznih in zanesljivih in vitro modelov nosnih in pljučnih epitelijskih barier je ključnega pomena pri vrednotenju permeabilnostnih lastnosti potencialnih zdravilnih učinkovin in formulacij, ki so namenjene nazalni in pulmunarni aplikaciji. In vitro modeli morajo ustrezno posnemati bariern ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Applicability of RPMI 2650 and Calu-3 cell models for evaluation of nasal formulations
Nadica Sibinovska, Simon Žakelj, Jurij Trontelj, Katja Kristan
Izvirni znanstveni članek
Oznake: RPMI 2650 cell line;Calu-3 cell line;nasal drug formulations;
The RPMI 2650 and Calu-3 cell lines have been previously evaluated as models of the nasal and airway epithelial barrier, and they have demonstrated the potential to be used in drug permeation studies. However, limited data exist on the utilization of these two cell models for the assessment of nasal ...
Leto: 2022 Vir: Repozitorij Univerze v Ljubljani (RUL)
Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way
Katja Berginc, Nadica Sibinovska, Simon Žakelj, Jurij Trontelj, Igor Legen
Izvirni znanstveni članek
Oznake: desloratadine;BCS-based bio-waiver;luminal stability;permeability;dissolution;
The biopharmaceutical classification of drugs was designed as a basis for bio-waivers % a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability a ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing
Larisa Tratnjek, Nadica Sibinovska, Slavko Kralj, Darko Makovec, Katja Kristan, Mateja Erdani-Kreft
Izvirni znanstveni članek
Oznake: esophageal adenocarcinoma;FLO-1 cell line;disease pathophysiology;
FLO-1 cell line represents an important tool in esophageal adenocarcinoma (EAC) research as a verified and authentic cell line to study the disease pathophysiology and antitumor drug screenings. Since in vitro characteristics of cells depend on the microenvironment and culturing conditions, we perfo ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
In vitro ciliotoxicity and cytotoxicity testing of repeated chronic exposure to topical nasal formulations for safety studies
Larisa Tratnjek, Nadica Sibinovska, Katja Kristan, Katja Kristan, Mateja Erdani-Kreft, Mateja Erdani-Kreft
Izvirni znanstveni članek
Oznake: formulacije zdravil za nos;mukociliarni očistek;citotoksičnost;nasal drug formulations;mucociliary clearance;cytotoxicity;
Certain active drugs and excipients of nasal formulations may impair ciliary function and mucociliary clearance. The ciliary beat frequency (CBF) is a key parameter for determining mucociliary clearance rate, and in vitro assessments of CBF have proven to be accurate and reproducible. Since topical ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 5
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