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Št. zadetkov: 2
Vitamin B3-based biologically active compounds as inhibitors of human cholinesterases
Antonio Zandona, Gabriela Lihtar, Nikola Maraković, Katarina Miš, Valentina Bušić, Dajana Gašo-Sokač, Sergej Pirkmajer, Maja Katalinić
Izvirni znanstveni članek
Oznake: Alzheimerjeva bolezen;nikotinamid;citotoksičnost;Alzheimer's disease;nicotinamide;cytotoxicity;
We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. As the results indic ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Investigation of paraoxonase-1 genotype and enzyme-kinetic parameters in the context of cognitive impairment in Parkinson’s disease
Boštjan Petrič, Sara Redenšek, Vita Dolžan, Milica Gregorič Kramberger, Maja Trošt, Nikola Maraković, Marko Goličnik, Aljoša Bavec, Aljoša Bavec
Izvirni znanstveni članek
Oznake: Parkinsonova bolezen;kognitivne motnje;paraoksonaza 1;Parkinson disease;cognitive impairment;paraoxonase 1;
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), which often progresses to PD dementia. PD patients with and without dementia may differ in certain biochemical parameters, which could thus be used as biomarkers for PD dementia. The enzyme paraoxonase 1 (PON1) has previ ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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