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Št. zadetkov: 8
Izvirni znanstveni članek
Oznake: paraoksonaza 1;dihidrokumarin;krivulje napredka;paraoxonase 1;dihydrocoumarin;progress curves;
Several approaches for determining an enzyme’s kinetic parameter Km (Michaelis constant) from progress curves have been developed in recent decades. In the present article, we compare different approaches on a set of experimental measurements of lactonase activity of paraoxonase 1 (PON1): (1) a diff ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake: Parkinsonova bolezen;kognitivne motnje;paraoksonaza 1;Parkinson disease;cognitive impairment;paraoxonase 1;
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), which often progresses to PD dementia. PD patients with and without dementia may differ in certain biochemical parameters, which could thus be used as biomarkers for PD dementia. The enzyme paraoxonase 1 (PON1) has previ ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake: paraoksonaza 1;Alzheimerjeva demenca;Parkinsonova bolezen;kognitivni upad;encimska kinetika;integrirana Michaelis-Mentenina enačba;laktonazna aktivnost;arilesterazna aktivnost;paraoksonazna aktivnost;
Ozadje: Encim paraoksonaza 1 (PON1) je prisoten v krvni plazmi, vezan na delce lipoproteinov visoke gostote (HDL) in ima antioksidativno vlogo. Njegovi fiziološki substrati niso dobro znani. Aktivnost PON1 v plazmi in polimorfizme (SNP) gena PON1 so preučevali pri blagi kognitivni motnji (BKM), pri ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake: paraoxonase;lactonase;oxidative stress;
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascul ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake: rekombinantna paraoksonaza 1;paraokson;2-hidroksikinolin;stabilnost proteinov;encimska aktivnost;magistrska dela;
Serumske paraoksonaze (PON) so proteinska družina pri sesalcih, ki jih sestavljajo encimi PON1, PON2 in PON3. Najbolj raziskan član družine je encim paraoksonaza 1 (PON1), ki ima laktonazno, arilesterazno in paraoksonazno aktivnost. Pomembno vpliva na preprečevanje srčno-žilnih in nevrodegenerativn ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake: paraoxonase-1;arylesterase activity;reversible inhibition;
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostig ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake: oropharyngeal cancer;xerostomia;mesenchymal stromal stem cells;
Background: Xerostomia is a common side effect of radiotherapy in patients with head and neck tumors that negatively affects quality of life. There is no known effective standard treatment for xerostomia. Here, we present the study protocol used to evaluate the safety and preliminary efficacy of all ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake: pluralizacija oblik družinskega življenja;tradicionalne vrednote;družine;nuklearna družina;reorganizirana družina;istospolna partnerska skupnost;funkcije družine;homofobija;homoseksualnost;nestrpnost;družinsko pravo;
Leto: 2015 Vir: Evropska pravna fakulteta v Novi Gorici (EVRO-PF)
Št. zadetkov: 8
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