Št. zadetkov: 19
Pregledni znanstveni članek
Oznake:
epitelno-mezenhimski prehod;družina mikroRNA-200;epigenetski dejavniki;epithelial–mesenchymal transition;microRNA-200 family;epigenetic factors;
Epithelial–mesenchymal transition (EMT) is a fundamental physiologically relevant process that occurs during morphogenesis and organ development. In a pathological setting, the transition from epithelial toward mesenchymal cell phenotype is hijacked by cancer cells, allowing uncontrolled metastatic ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
maligni tumorji jeter;metastaze v jetrih;biopsija;malignant liver tumors;liver metastases;biopsy;
Malignant liver tumors include primary malignant liver tumors and liver metastases. They are among the most common malignancies worldwide. The disease has a poor prognosis and poor overall survival, especially with liver metastases. Therefore, early detection and differentiation between malignant li ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
Adenokacinomi jeter;hepatocelularni karcinom;holangiokarcinom;adenokarcinom debelega črevesa in danke;duktalni adenokarcinom trebušne slinavke;zasevki v jetrih;bioinformacijska analiza;MS-HRM;dPCR;metilacija DNA;izražanje genov.;
Metilacijski označevalci veljajo za eno izmed obetavnih epigenetskih značilnosti raka za diagnosticiranje in razlikovanje adenokarcinomov jeter, ki sodijo med najpogostejša maligna obolenja na svetu. Namen doktorske naloge je bil prepoznati in eksperimentalno potrditi nove diagnostične metilacijske ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
kronična vnetna črevesna bolezen;fibroza;miofibroblasti;izražanje genov;subseroza;
V doktorskem delu smo raziskali, kateri geni in celice so vključeni v patogenezo fibroze pri kronični vnetni črevesni bolezni (KVČB). Fibroza je pogost zaplet KVČB, predvsem v Crohnovi bolezni (CB), za katero je značilna izrazita fibroza in transmuralno vnetje, ter v mnogo manjši meri pri ulceroznem ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
dolgo nekodirajoči DNA;rak;onkogeni lncRNA;long non-coding DNA;cancer;oncogenic lncRNA;
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating ...
Leto:
2013
Vir:
Medicinska fakulteta (UL MF)
Objavljeni znanstveni prispevek na konferenci
Oznake:
microRNAs;long non-coding RNAs;biomarker;
Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potentialbiomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic andprognostic biomarkers, and as therapeutic tools in cancer, since their expression pr ...
Leto:
2013
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Doktorska disertacija
Oznake:
delni EMP;kolorektalni karcinom;laserska mikrodisekcija;mikro RNA;zasevanje;
V doktorskem delu smo raziskali pomen epitelijsko-mezenhimskega prehoda (EMP) in mezenhimsko-epitelijskega prehoda (MEP) pri napredovanju in zasevanju raka debelega črevesa in danke (RDČD).
V prvem delu smo pokazali, da imata EMP in MEP pomembno vlogo pri napredovanju in zasevanju RDČD, vendar ne k ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
vnetne črevesne bolezni;fibroza;Crohnova bolezen;inflammatory bowel diseases;fibrosis;Crohn’s disease;
Fibrosis is an important feature of inflammatory bowel diseases (IBD), but its pathogenesis is incompletely understood. Our aim was to identify genes important for fibrosis in IBD by comparison with kidney and liver fibrosis. First, we performed bioinformatics analysis of Gene Expression Omnibus dat ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Crohn’s disease;fibrostenosis;inflammatory stenosis;fibrosis;miRNA;
Crohn’s disease (CD) is frequently complicated by strictures that can be either inflammatory or fibrostenotic. This distinction is important for deciding the best treatment course, but it can be difficult to determine clinically, sometimes even by advanced imaging techniques. We performed miRNA PCR ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
web aplication;RNA expression;colorectal cancer;gene expression;knowledge base;cancer genome atlas;miRNA;mRNA;gene correlation;target genes;
"miRNA colorectal cancer" (https://mirna-coadread.omics.si/) is a freely available web application for studying microRNA and mRNA expression and their correlation in colorectal cancer. To the best of our knowledge, %miRNA colorectal cancer% has the largest knowledge base of miRNA-target gene express ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
