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Št. zadetkov: 7
Expression of fibrosis-related genes in liver and kidney fibrosis in comparison to inflammatory bowel diseases
Miha Jerala, Nina Hauptman, Nika Kojc, Nina Zidar, Nina Zidar
Izvirni znanstveni članek
Oznake: vnetne črevesne bolezni;fibroza;Crohnova bolezen;inflammatory bowel diseases;fibrosis;Crohn’s disease;
Fibrosis is an important feature of inflammatory bowel diseases (IBD), but its pathogenesis is incompletely understood. Our aim was to identify genes important for fibrosis in IBD by comparison with kidney and liver fibrosis. First, we performed bioinformatics analysis of Gene Expression Omnibus dat ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Pathology of fibrosis in Crohn's disease-contribution to understanding its pathogenesis
Nina Zidar, Cord Langner, Miha Jerala, Emanuela Boštjančič, David Drobne, Aleš Tomažič
Izvirni znanstveni članek
Oznake: Crohn's disease;fibrosis;stenosis;pathology;pathogenesis;
Background: Despite significant progress in the research of fibrosis in various organs, fibrosis remains a poorly understood complication of Crohn's disease (CD). We analyzed pathologic features of fibrosis and inflammation in CD and compared them with the normal bowel, aiming to clarify whether fib ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Expression of cytokine-coding genes BMP8B, LEFTY1 and INSL5 could distinguish between ulcerative colitis and Crohn's disease
Daša Jevšinek Skok, Nina Hauptman, Miha Jerala, Nina Zidar, Nina Zidar
Izvirni znanstveni članek
Oznake: vnetje črevesja;ulcerozni kolitis;Crohnova bolezen;inflammatory bowel disease;ulcerative colitis;Crohn's disease;
Ulcerative colitis (UC) and Crohn%s disease (CD) are characterized by an imbalance between pro-inflammatory and anti-inflammatory cytokines, interfering with the resolution of inflammation. Due to the crucial role of cytokines, new insights into their profiles in UC and CD would help to improve our ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Analiza možnosti realizacije primitivnih računalniških struktur na osnovi DNK gradnikov
Božidara Cvetković, Miha Mraz, Roman Jerala
Diplomsko delo
Oznake: biokocke;bioračunalništvo;nanoračunalništvo;bio logična vrata;večcelični sistemi;računalništvo;univerzitetni študij;diplomske naloge;
Analiza možnosti realizacije primitivnih računalniških struktur na osnovi DNK gradnikov
Leto: 2008 Vir: Fakulteta za računalništvo in informatiko (UL FRI)
Imunoterapija raka
Špela Malenšek, Roman Jerala, Janez Plavec, Miha Pavšič, Gregor Gunčar
Magistrsko delo
Oznake: rakava obolenja;imunoterapija raka;adaptivni imunski odziv;celice CAR-T;heterodimerizacija;rapamicin;giberelin;abscizinska kislina;magistrska dela;
Razvoj terapevtskih postopkov rakavih obolenj se zaradi kompleksnosti slednjih nagiba k usmerjenim in personaliziranim adaptivnim celičnim terapijam. Mednje sodijo celice CD19 CAR-T, pri čemer pacientovim limfocitom T vstavimo receptor CAR, specifičen za B-limfocitni antigen CD19. Terapija je uspešn ...
Leto: 2019 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Ovrednotenje vpliva aktivacije z AMP aktivirane protein kinaze na inflamasom NLRP3
Rok Miklavčič, Iva Hafner Bratkovič, Gregor Gunčar, Miha Pavšič, Roman Jerala
Magistrsko delo
Oznake: proteini;prirojen imunski sistem;inflamasomi;NLRP3;staranje;AMPK;avtofagija;magistrska dela;
Inflamasom NLRP3 je večproteinski kompleks prirojene imunosti in služi za aktivacijo kaspaze 1, ki proteolitično aktivira IL-1β, IL-18 in gasdermin D. Po aktivaciji NLRP3 se zreli obliki interlevkinov sprostita v okolico celic preko por gasdermina D ali zaradi nekroze in sprožita vnetje. Sestavljanj ...
Leto: 2020 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Engineered combinatorial cell device for wound healing and bone regeneration
Lucija Kadunc, Duško Lainšček, Rok Gašperšič, Petra Sušjan, Uroš Kovačič, Miha Butinar, Boris Turk, Roman Jerala, Iva Hafner Bratkovič
Izvirni znanstveni članek
Oznake: celjenje ran;regeneracija kosti;rastni faktorji;wound healing;bone regeneration;growth factors;
Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors underlies stem cell–mediated regeneration. To avoid the potential dangers and laborinten ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 7
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