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Št. zadetkov: 4
ǂThe ǂrole of pyruvate dehydrogenase and STING-TBK1 signaling pathway in the regulation of energy metabolism via AMP-activated protein kinase in skeletal muscles
Nives Škorja, Sergej Pirkmajer
Doktorska disertacija
Oznake: AMPK;pyruvate dehydrogenase kinase;dichloroacetate;cGAS-STING-TBK1 signaling pathway;2'3'-cGAMP;DMXAA;AMPK activators;insulin;skeletal muscle cells;iPSCs-derived skeletal muscle cells;cancer cells;Fiziologija človeka;Disertacije;Mišične celice;Energijska presnova;Metabolne poti;Biokemijske reakcije;
NAMEN: Splošni namen doktorske disertacije je bil preučiti molekularne mehanizme, prek katerih skeletne mišice uravnavajo delovanje z AMP-aktivirane protein kinaze (AMPK) v fizioloških in patofizioloških stanjih, katerih posledica je indukcija imunskega odziva. Poleg tega je bil cilj pojasniti tudi ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Vpliv metformina na mitohondrijski potencial in presnovo laktata v celicah raka dojke
Nives Škorja, Sergej Pirkmajer, Sergej Pirkmajer, Marko Kreft, Marko Kreft, Tom Turk
Magistrsko delo
Oznake: metabolizem rakavih celic;metformin;celice raka dojke;mitohondrijski potencial;nastanek laktata;
Vpliv metformina na mitohondrijski potencial in presnovo laktata v celicah raka dojke
Leto: 2016 Vir: Biotehniška fakulteta (UL BF)
Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes
Blaž Kociper, Nives Škorja, Ivana Ogrizek, Katarina Miš, Sergej Pirkmajer, Sergej Pirkmajer
Izvirni znanstveni članek
Oznake: chloroquine;hypoxia-inducible factor-1α (HIF-1α);MG132;myotubes;PYR-41;pyruvate dehydrogenase kinase 1 (PDK1);
Pyruvate dehydrogenase kinase (PDK), which phosphorylates the pyruvate dehydrogenase complex, regulates glucose metabolism in skeletal muscle. PDK1, an isozyme whose expression is controlled by hypoxia-inducible factor-1α (HIF-1α), is thought to play a role in muscle adaptation to hypoxia. While tra ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Suppression of pyruvate dehydrogenase kinase by dichloroacetate in cancer and skeletal muscle cells is isoform specific and partially independent of HIF-1[alpha]
Nives Škorja, Klemen Dolinar, Katarina Miš, Urška Matkovič, Maruša Rajh, Mojca Pavlin, Matej Podbregar, Sergej Pirkmajer, Sergej Pirkmajer
Izvirni znanstveni članek
Oznake: celice skeletnih mišic;rak;dikloroacetat;skeletal muscle cells;cancer;dichloroacetate;
Inhibition of pyruvate dehydrogenase kinase (PDK) emerged as a potential strategy for treatment of cancer and metabolic disorders. Dichloroacetate (DCA), a prototypical PDK inhibitor, reduces the abundance of some PDK isoenzymes. However, the underlying mechanisms are not fully characterized and may ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 4
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