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Identification of a conserved chemokine receptor motif that enables ligand discrimination
Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake: GTP-binding proteins;monocyte chemoattractant proteins;macrophage inflammatory proteins;receptors;chemokine;
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic receptor residues that ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 1
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