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Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Žiga Skok, Michaela Barančokova, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašić, Nace Zidar, Lucija Peterlin-Mašič, Anamarija Zega, Danijel Kikelj, Janez Ilaš
Izvirni znanstveni članek
Oznake: DNA gyrase;topoisomerase IV;GyrB;ParE;antibacterial benzothiazole;
We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the antibacterial activity and retain potent enzymatic activity, we systematically explo ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
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