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Št. zadetkov: 2
SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in [beta] cell networks
Teresa Daraio, Lidija Križančić Bombek, Marko Gosak, Ismael Valladolid-Acebes, Maša Skelin, Essam Refai, Per-Olof Berggren, Kerstin Brismar, Marjan Rupnik, Christina Bark
Izvirni znanstveni članek
Oznake: insulin secretion;pre-diabetes;
SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic [beta] cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic [beta] cells rem ...
Leto: 2017 Vir: Medicinska fakulteta (UM MF)
Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic [alpha]-cells
Vladimir Grubelnik, Rene Markovič, Saška Lipovšek Delakorda, Gerd Leitinger, Marko Gosak, Jurij Dolenšek, Ismael Valladolid-Acebes, Per-Olof Berggren, Andraž Stožer, Matjaž Perc, Marko Marhl
Izvirni znanstveni članek
Oznake: diabetes;alfa celice;glukagon;mithondrijska disfunkcija;proste maščobne kisline;ne zaključna dela;pancreatic alpha cells;glucagon;mitochondrial dysfunction;free fatty acid;
Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have had limited success. The focus is therefore shifting ...
Leto: 2020 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Št. zadetkov: 2
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