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Št. zadetkov: 6
Transcendentalna meditacija in njeni učinki na telesno in duševno zdravje
Petra Kikelj, Emil Karajić
Diplomsko delo
Oznake: transcendentalna meditacija;duševno zdravje;telesno zdravje;možgani;hormonski sistem;druge meditacije;diplomske naloge;
Teoretična izhodišča: Telesno in duševno zdravje predstavljata perečo problematiko po vsem svetu, ne nazadnje tudi zaradi pandemije Covida 19. Namen raziskave je raziskati delovanje transcendentalne meditacije ter njeno učinkovitost na telesno in duševno zdravje. Metoda: Uporabljen je bil kritični ...
Leto: 2022 Vir: Fakulteta za uporabne družbene študije v Novi Gorici (FUDŠ)
Rational design of balanced dual-targeting antibiotics with limited resistance
Ákos Nyerges, Tihomir Tomašić, Martina Durcik, Tamás Révész, Petra Éva Szili, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin-Mašič
Izvirni znanstveni članek
Oznake: antibiotics;bacterial resistance;bacterial targets;
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workfl ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Nace Zidar, Alessia Onali, Peter Peršolja, Davide Benedetto Tiz, Jaka Dernovšek, Žiga Skok, Martina Durcik, Andrej Emanuel Cotman, Martina Hrast, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Danijel Kikelj
Izvirni znanstveni članek
Oznake: antibacterial;DNA gyrase;GyrB;inhibitor;N-phenylpyrrolamide;ParE;topoisomerase IV;
In this work, we describe an improved series of N-phenylpyrrolamide inhibitors that exhibit potent activity against DNA gyrase and are highly effective against high-priority gram-positive bacteria. The most potent compounds show low nanomolar IC50 values against Escherichia coli DNA gyrase, and in a ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
Andrej Emanuel Cotman, Federica Fulgheri, Martina Piga, Peter Peršolja, Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Maša Sterle, Jaka Dernovšek, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Danijel Kikelj, Nace Zidar
Izvirni znanstveni članek
Oznake: N-fenilpirolamidni inhibitorji;bakterijske DNA giraze;sinteza spojin;antibakterijsko delovanje;
This study presents the discovery of a new series of N-phenylpyrrolamide inhibitors of bacterial DNA gyrase with improved antibacterial activity. The most potent inhibitors had low nanomolar IC50 values against Escherichia coli DNA gyrase (IC50; 2–20 nM) and E. coli topoisomerase IV (22i, IC50 = 143 ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Hybrid inhibitors of DNA gyrase A and B
Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Éva Szili, Gábor Draskovits, Tamás Révész, Danijel Kikelj, Ákos Nyerges, Csaba Pál, Lucija Peterlin-Mašič, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: antibacterial;ciprofloxacin;DNA gyrase;dual inhibitor;hybrid;
The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Exploring the 5-substituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens
Maša Sterle, Martina Durcik, Clare E. M. Stevenson, Sara R. Henderson, Petra Eva Szili, Marton Czikkely, David M. Lawson, Danijel Kikelj, Nace Zidar, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Andrej Emanuel Cotman, Anamarija Zega
Izvirni znanstveni članek
Oznake: inhibitorji;organske kisline;proteini;bacteria;genetics;inhibitors;organic acids;peptides;proteins;
We present a new series of 2-aminobenzothiazole-based DNA gyrase B inhibitors with promising activity against ESKAPE bacterial pathogens. Based on the binding information extracted from the cocrystal structure of DNA gyrase B inhibitor A, in complex with Escherichia coli GyrB24, we expanded the chem ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 6
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