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Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction
Elisa Avolio, Giuseppe Gianfranceschi, Daniela Cesselli, Angela Caragnano, Emmanouil Athanasakis, Rajesh Katare, Marco Meloni, Anita Palma, Arianna Barchiesi, Carlo Vascotto, Elisa Mazzega
Izvirni znanstveni članek
Oznake: stem cells;myocardial infarction;heart failure;cellular senescence;
Cardiac stem cells (CSC) from explanted decompensated hearts (E-CSC) are, with respect to those obtained from healthy donors (D-CSC), senescent and functionally impaired. We aimed to identify alterations in signaling pathways that are associated with CSC senescence. Additionally, we inves- tigated i ...
Leto: 2014 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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