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Št. zadetkov: 5
Local estrogen biosynthesis and the roles of SLC and ABC gene families of transporter proteins in endometrial and ovarian cancers
Renata Pavlič, Tea Lanišnik-Rižner
Doktorska disertacija
Oznake: Ginekologija;Disertacije;Bolezni endometrija;Jajčniki;Estrogen;Onkologija;Rak jajčnikov;Hormoni;Endometrij;Prenašalni proteini;
Ozadje Rak endometrija in rak jajčnikov sta pogosti hormonsko-odvisni ginekološki bolezni, ki sta v svetovnem merilu v letu 2020 prizadeli več kot 700 000 žensk in povzročili več kot 300 000 smrti. Razvoj obeh bolezni je pogostejši pri ženskah po menopavzi, ko se sinteza estrogenov iz jajčnikov preu ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Model cell lines and tissues of different HGSOC subtypes differ in local estrogen biosynthesis
Renata Pavlič, Marija Gjorgoska, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: rak jajčnikov;serozni karcinom jajčnikov visoke stopnje;HIO-80;ovarian cancer;high-grade serous ovarian carcinoma;
Ovarian cancer (OC) is highly lethal and heterogeneous. Several hormones are involved in OC etiology including estrogens; however, their role in OC is not completely understood. Here, we performed targeted transcriptomics and estrogen metabolism analyses in high-grade serous OC (HGSOC), OVSAHO, Kura ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Metabolism of estrogens
Stefan Poschner, Judith Wackerlig, Dan Cacsire Castillo-Tong, Andrea Wolf, Isabel von der Decken, Tea Lanišnik-Rižner, Renata Pavlič, Anastasia Meshcheryakova
Izvirni znanstveni članek
Oznake: serozni rak jajčnika visoke stopnje;steroidni hormoni;metabolomics;high-grade serous ovarian cancer;steroid hormones;
High-grade serous ovarian cancer (HGSOC) is currently treated with cytoreductive surgery and platinum-based chemotherapy. The majority of patients show a primary response; however, many rapidly develop drug resistance. Antiestrogens have been studied as low toxic treatment options for HGSOC, with hi ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Altered profile of E1-S transporters in endometrial cancer
Renata Pavlič, Suzana Vidic, Maja Anko, Tamara Knific, Tomaž Büdefeld, Kristina Marton, Maša Sinreih, Stefan Poschner, Walter Jäger, Snježana Frković-Grazio, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: rak endometrija;intrakrinologija;organski polipeptidi, ki prenašajo anione;endometrial cancer;intracrinology;organic anion-transporting polypeptides;
Endometrial cancer (EC) is associated with increased estrogen actions. Locally, estrogens can be formed from estrone-sulphate (E1-S) after cellular uptake by organic anion-transporting polypeptides (OATP) or organic anion transporters (OAT). Efflux of E1-S is enabled by ATP Binding Cassette transpor ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
Jakob Kljun, Renata Pavlič, Eva Hafner, Tanja Lipec, Sara Moreno-Da Silva, Primož Tič, Iztok Turel, Iztok Turel, Tomaž Büdefeld, Jure Stojan, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: ruthenium complexes;synthesis;crystal structure;
In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1–6) and hydroxyquinolinate (7–10) chelating ligands with t ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 5
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