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Št. zadetkov: 3
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
Monika Štimac, Urška Kamenšek, Maja Čemažar, Richard Heller, Gregor Serša
Izvirni znanstveni članek
Oznake: gene therapy;electrotransfer;plasmid;irradiation;immune response;melanoma;
Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for ...
Leto: 2017 Vir: Onkološki inštitut Ljubljana (OI)
Biological factors of the tumour response to electrochemotherapy
Gregor Serša, Katja Uršič, Maja Čemažar, Richard Heller, Maša Bošnjak, Luca Giovanni Campana
Pregledni znanstveni članek
Oznake: biološki dejavniki;biološki označevalci;elektrokemoterapija;bleomycin;cisplatin;biological factors;biomarkers;electrochemotherapy;
The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deepseated malignancies in terms of local control and quality of life are widely accepted. However, the variability in responses across histotypes needs to be explored. Currently, patient selection for EC ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Potentiation of electrochemotherapy effectiveness by immunostimulation with IL-12 gene electrotransfer in mice is dependent on tumor immune status
Katja Uršič, Špela Kos, Urška Kamenšek, Maja Čemažar, Simona Miceska, Boštjan Markelc, Simon Buček, Barbara Starešinič, Veronika Kloboves-Prevodnik, Richard Heller, Gregor Serša
Izvirni znanstveni članek
Oznake: elektrokemoterapija;elektroprenos genov;interlevkin-12;electrochemotherapy;gene electrotransfer;interleukin-12;
Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. Therefore, we designed a combination therapy consisting of ECT via intratumoral application of bleomycin, oxaliplatin or cisplatin with p ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Št. zadetkov: 3
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