Št. zadetkov: 8
Izvirni znanstveni članek
Oznake:
baricitinib;COVID-19;devteracija;označevanje z devterijem;SARS-CoV-2;izotopolog;deuteration;deuterium-labelled;isotopologue;
Baricitinib, typically applied as a treatment for rheumatoid arthritis, has recently attracted the attention of clinicians and researchers as a potential treatment for COVID-19. Naturally, there has been a need for the preparation of the isotope-labelled analogue of baricitinib to probe the pharmaco ...
Leto:
2022
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Pregledni znanstveni članek
Oznake:
COVID-19;izotopi vodika;inhibitorji;presnova;zdravila;hydrogen isotopes;inhibitors;metabolism;pharmaceuticals;
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan (China) in December 2019, COVID-19 rapidly spread globally, resulting in the COVID-19 pandemic. Carriers of the SARS-CoV-2 can ...
Leto:
2022
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
coordination;boron hydride;
We have developed an efficient and versatile approach for the synthesis of a family of 1,2,3-triazole-based mesoionic N-heterocyclic olefin (mNHO) ligands and investigated their coordination to palladium, gold, and boron hydride experimentally and computationally. We reacted mNHOs obtained through d ...
Leto:
2024
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
devteriranje;usmerjeno orto-metaliranje;orto-devteriranje;N-heterocikli;O-karbamati;karboksamidi;deuteration;directed ortho-matalation;ortho-deuteration;N-heterocycles;O-carbamates;carboxamides;
Selectively deuterated electron-deficient N-containing heteroaromatic systems can enable modulation of metabolism with enhanced therapeutic efficacy in pharmaceuticals and improved properties and stability of functional materials, e.g., imaging dyes, light emitters, and catalysts. Current synthetic ...
Leto:
2025
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Pregledni znanstveni članek
Oznake:
deuteriranje;devterij;označevanje z devterijem;označevanje z izotopi;N-heteroaren;N-heteroaromatski;piridin;pirimidin;pirazin;piridazin;kinolin;kinazolin;elektronsko pomanjkljiv;triazin;tetrazin;organska elektronika;farmacevtski izdelki;barvila;deuteration;deuterium;deuterium-labelling;isotope-labelling;N-heteroarene;N-heteroaromatic;pyridine;pyrimidine;pyrazine;pyridazine;quinoline;quinazoline;electron-deficient;triazine;tetrazine;organic electronics;pharmaceuticals;dyes;
Six-membered N-heteroarenes (“6NHetAr”) play pivotal roles in the pharmaceutical, agrochemical, and materials science industries. In recent times, deuterium (D)-labelled 6NHetAr have demonstrated enhanced performance over their unlabelled counterparts. For example, VV116 and VX-984, approved therape ...
Leto:
2025
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Pregledni znanstveni članek
Oznake:
aril O-karbamat;metalizacija;preureditev;navzkrižna sklopitev;regioselektivnost;usmerjevalna skupina;aryl O-carbamate;metalation;rearrangement;cross coupling;regioselective;directing group;
The aryl O-carbamate (ArOAm) group is among the strongest of the directed metalation groups (DMGs) in directed ortho metalation (DoM) chemistry, especially in the form Ar-OCONEt$_2$. Since the last comprehensive review of metalation chemistry involving ArOAms (published more than 30 years ago), the ...
Leto:
2024
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Pregledni znanstveni članek
Oznake:
imobiliziran;recikliranje;deuteriran;deuterogenacija;deuteracija;deuterodehalogenacija;deuterodekarboksilacija;immobilized;recyclable;deuterated;deuterogenation;deuteration;deuterodehalogenation;deuterodecarboxylation;
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes, catalysts, and light emitters. Conventionally, the synthesis of D-labelled compounds relies on (bio)ca ...
Leto:
2025
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Luka Rejc,
Damijan Knez,
Gabriela Molina-Aguirre,
Alba Espargaró,
Jerneja Kladnik,
Anže Meden,
Lana Blinc,
Matic Lozinšek,
Ross D. Jansen-van Vuuren,
Matic Rogan,
Bruno Aleksander Martek,
Jernej Mlakar,
Ana Dremelj,
Andrej Petrič,
Stanislav Gobec,
Mara Bresjanac,
Janez Košmrlj
Izvirni znanstveni članek
Oznake:
amyloid beta;fluorophore;solvatochromism;synthesis;photophysics;
Fluorescent probes are a powerful tool for imaging amyloid β (Aβ) plaques, the hallmark of Alzheimer’s disease (AD). Herein, we report the synthesis and comprehensive characterization of 21 novel probes as well as their optical properties and binding affinities to Aβ fibrils. One of these dyes, 1Ae, ...
Leto:
2024
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)