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Št. zadetkov: 4
Synthesis of [ [sup] 2H [sub] 5]baricitinib via [ [sup] 2H [sub] 5]ethanesulfonyl chloride
Ross D. Jansen-van Vuuren, Rahul Vohra
Izvirni znanstveni članek
Oznake: baricitinib;COVID-19;devteracija;označevanje z devterijem;SARS-CoV-2;izotopolog;deuteration;deuterium-labelled;isotopologue;
Baricitinib, typically applied as a treatment for rheumatoid arthritis, has recently attracted the attention of clinicians and researchers as a potential treatment for COVID-19. Naturally, there has been a need for the preparation of the isotope-labelled analogue of baricitinib to probe the pharmaco ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Deuterated drugs and biomarkers in the COVID-19 pandemic
Ross D. Jansen-van Vuuren, Luka Jedlovčnik, Janez Košmrlj, Thomas E. Massey, Volker Derdau
Pregledni znanstveni članek
Oznake: COVID-19;izotopi vodika;inhibitorji;presnova;zdravila;hydrogen isotopes;inhibitors;metabolism;pharmaceuticals;
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan (China) in December 2019, COVID-19 rapidly spread globally, resulting in the COVID-19 pandemic. Carriers of the SARS-CoV-2 can ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Towards structurally versatile mesoionic N-heterocyclic olefin ligands and their coordination to palladium, gold, and boron hydride
Tisa Ževart, Balazs Pinter, Matic Lozinšek, Damijana Urankar, Ross D. Jansen-van Vuuren, Janez Košmrlj
Izvirni znanstveni članek
Oznake: coordination;boron hydride;
We have developed an efficient and versatile approach for the synthesis of a family of 1,2,3-triazole-based mesoionic N-heterocyclic olefin (mNHO) ligands and investigated their coordination to palladium, gold, and boron hydride experimentally and computationally. We reacted mNHOs obtained through d ...
Leto: 2024 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
ǂThe ǂversatile and strategic O-carbamate directed metalation group in the synthesis of aromatic molecules
Ross D. Jansen-van Vuuren, Susana Liu, M. A. Jalil Miah, Janez Cerkovnik, Janez Košmrlj, Victor Snieckus
Pregledni znanstveni članek
Oznake: aril O-karbamat;metalizacija;preureditev;navzkrižna sklopitev;regioselektivnost;usmerjevalna skupina;aryl O-carbamate;metalation;rearrangement;cross coupling;regioselective;directing group;
The aryl O-carbamate (ArOAm) group is among the strongest of the directed metalation groups (DMGs) in directed ortho metalation (DoM) chemistry, especially in the form Ar-OCONEt$_2$. Since the last comprehensive review of metalation chemistry involving ArOAms (published more than 30 years ago), the ...
Leto: 2024 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Št. zadetkov: 4
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