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Št. zadetkov: 4
Vpliv kemoterapije na metabolizem matičnih in diferenciranih glioblastomskih celic
Simona Katrin Galun, Metka Novak, Urban Bogataj, Miloš Vittori
Magistrsko delo
Oznake: glioblastom;diferencirane celice glioblastoma;matične celice glioblastoma;temozolomid;endotelijske celice;tumorsko mikrookolje;
Glioblastom je možganski tumor s slabo prognozo preživetja. Matične celice glioblastoma (GSC) igrajo pomembno vlogo pri odpornosti na terapijo zaradi sposobnosti diferenciacije in zagotavljanjem heterogenosti. Ohranjanje teh lastnosti je povezano z njihovimi interakcijami s tumorskim mikrookoljem (T ...
Leto: 2024 Vir: Biotehniška fakulteta (UL BF)
Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells
Urban Bogataj, Metka Novak, Simona Katrin Galun, Klementina Fon Tacer, Miloš Vittori, Cornelis J. F. van Noorden, Barbara Breznik
Izvirni znanstveni članek
Oznake: glioblastoma;mitochondria;metabolism;chemotherapy;stem cells;
Background[:] Glioblastoma stem-like cells (GSCs) contribute to the resistance of glioblastoma (GBM) tumors to standard therapies. The background of the resistance of GSCs to the chemotherapeutic agent temozolomide is not yet fully understood in the context of cellular metabolism and the role of mit ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases
Metka Novak, Bernarda Majc, Marija Skoblar Vidmar, Špela Kladnik, Tina Kolenc Milavec, Anamarija Habič, Simona Katrin Galun, Pia Žižek, Andrej Porčnik, Alenka Matjašič, Andrej Zupan, Miha Jerala, Matic Bošnjak, Borut Prestor, Barbara Breznik
Izvirni znanstveni članek
Oznake: glioblastom;redek klinični primer;MEK inhibitor;rakave matične celice;glioblastoma;extraneural metastasis;rare clinical case;organoids;cancer stem cells;cell invasion;
Glioblastoma (GBM) remains one of the most lethal human malignancies, yet extraneural metastases are exceptionally rare and poorly understood. Standard treatment—surgical resection followed by chemoradiotherapy—offers only modest survival benefits, and therapeutic options for metastatic GBM are limi ...
Leto: 2026 Vir: Nacionalni inštitut za biologijo (NIB)
New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases
Cornelis J. F. van Noorden, Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, Katrin S. Galun, Miloš Vittori, Mateja Erdani-Kreft, Metka Novak, Barbara Breznik, Vashendriya V. V. Hira
Pregledni znanstveni članek
Oznake: aerobic glycolysis;anaerobic glycolysis;angiogenesis;ATP synthesis;cancer cells;cancer stem cells;endothelial cells;energy metabolism;eye diseases;oxidative phosphorylation;pericytes;retina;Warburg effect;
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and ...
Leto: 2024 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 4
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