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Št. zadetkov: 3
Identification and analysis of dynamic RNA hubs during early murine embryonic development
Tajda Klobučar, Miha Modic
Doktorska disertacija
Oznake: condensation;RNA hub;ribonucleoproteins;RIC-seq;mouse embryonic stem cells;
Early mouse embryonic development proceeds through tightly regulated transitions by specific molecular mechanisms and signalling pathways. Among the implicated mechanisms, complex RNA-protein networks are emerging as important factors. While ribonucleoproteins (RNPs) are known to play a crucial role ...
Leto: 2026 Vir: Biotehniška fakulteta (UL BF)
Integrative profiling of condensation-prone RNAs during early development
Tajda Klobučar, Jona Novljan, Ira Alexandra Iosub, Boštjan Kokot, Iztok Urbančič, D. Marc Jones, Anob M. Chakrabarti, Nicholas M. Luscombe, Jernej Ule, Miha Modic
Izvirni znanstveni članek
Oznake: biokemija;beljakovine;RNK;zaporedja;interakcije med RNK in RNK;condensation-prone RNAs;RNA-RNA interactions;phase separation;
Complex RNA-protein networks play a pivotal role in the formation of many types of biomolecular condensates. How RNA features contribute to condensate formation, however, remains incompletely understood. Here, we integrate tailored transcriptomics assays to identify a distinct class of developmental ...
Leto: 2026 Vir: Kemijski inštitut (KI)
Characterization of genomic imprinting defects during mouse iPSC generation
Tajda Klobučar, Jernej Ogorevc, Jernej Ogorevc, Simão José Teixeira da Rocha, Simão José Teixeira da Rocha, Mojca Narat, Uroš Petrovič, Uroš Petrovič
Magistrsko delo
Oznake: induced pluripotent stem cells;genomic imprinting;DNA methylation;
Induced pluripotent stem cells (iPSCs) can be obtained from somatic cells through a dynamic process of reprogramming and represent an important step towards personalized regenerative medicine. Unfortunately, through available reprogramming protocols, iPSCs still acquire several genetic and epigeneti ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 3
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