Št. zadetkov: 11
Kratki znanstveni prispevek
Oznake:
glioblastoma;matične celice;akutna mielonična levkemija;kostni mozeg;glioblastoma stem cells;niches;acute myeloid leukemia;hematopoietic stem cells;bone marrow;C-X-C receptor type 4;stromal-derived factor-1 ▫$[alpha]$▫;plerixafor;
Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs a ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
glioblastoma;endotelne celice;tumorsko mikrookrožje;hipoksija;glioma stem cells;niches;blood vessels;extracellular matrix;tumor microenvironment;hypoxia;therapy resistance;vasculature;
Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radi ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
2D transwell invasion assay;3D spheroid invasion assay;cancer cell;cellular invasion;glioblastoma stem cells;
Invasion is a hallmark of cancer and therefore in vitro invasion assays are important tools in cancer research. We aimed to describe in vitro 2D transwell assays and 3D spheroid assays to quantitatively determine the invasive behavior of glioblastoma stem cells in response to the chemoattractant SDF ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
medicinske znanosti;levkemija;zdravljenje;terapevtske strategije;hematopoietic stem cell niche;hijacking;leukemic stem cells;bone marrow;therapy resistance;leukemia;
Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are ...
Leto:
2017
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
glioblastoma stem cells;IDH1-mutation;energy metabolism;
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for cells and have anti-cancer effects. ROS are produced in the mitochondria during ATP production by oxidative phosphorylation (OXPHOS). In the present review, we describe ATP production in primary brain tumors, g ...
Leto:
2021
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
immunohistochemistry;chromogens;aminoethyl carbazole;AEC;3,3'-diaminobenzidine;DAB;antigen retrieval;tonsil;
Immunohistochemistry (IHC) specifically localizes proteins in cells and tissues, but methodologies vary widely. Therefore, we performed a methodological IHC optimization and validation study. First, we compared advantages and disadvantages of cryostat sections versus paraffin sections. Second, we co ...
Leto:
2019
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
cysteine cathepsins;glioblastoma stem cells;niches;stroma;proteolytic activity;
Glioblastoma (GBM) is the most lethal brain tumor also due to malignant and therapy-resistant GBM stem cells (GSCs) that are localized in protecting hypoxic GSC niches. Some members of the cysteine cathepsin family of proteases have been found to be upregulated in GBM. Cathepsin K gene expression is ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
izocitrat dehidrogenaza;kemosenzibilnost;cis-diamminedichloroplatinum;2-hidroksiglutarat;isocitrate dehydrogenase;chemosensitivity;2-hydroxyglutarate;
Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1MUT) enzymes consume NADPH to produce D-2-hydroxyglutarate (D-2HG) resulting ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Vashendriya V. V. Hira,
Urška Verbovšek,
Barbara Breznik,
Matic Srdič,
Marko Novinec,
Hala Kakar,
Jill Wormer,
Britt van der Swaan,
Brigita Lenarčič,
Luiz Juliano,
Shwetal Mehta,
Cornelis J. F. van Noorden,
Tamara Lah Turnšek
Izvirni znanstveni članek
Oznake:
glioma stem-like cells;niche;stromal derived factor-[alpha];cathepsin K;
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor patient survival that is at least partly caused by malignant and therapy-resistant glioma stem-like cells (GSLCs) that are protected in GSLC niches. Previously, we have shown that the chemo-attractant stromal-derived factor-1α ( ...
Leto:
2017
Vir:
Nacionalni inštitut za biologijo (NIB)
Cornelis J. F. van Noorden,
Bahar Yetkin-Arik,
Paola Serrano Martinez,
Noëlle Bakker,
Mathilda E. van Breest Smallenburg,
Reinier O. Schlingemann,
Ingeborg Klaassen,
Bernarda Majc,
Anamarija Habič,
Urban Bogataj,
Katrin S. Galun,
Miloš Vittori,
Mateja Erdani-Kreft,
Metka Novak,
Barbara Breznik,
Vashendriya V. V. Hira
Pregledni znanstveni članek
Oznake:
aerobic glycolysis;anaerobic glycolysis;angiogenesis;ATP synthesis;cancer cells;cancer stem cells;endothelial cells;energy metabolism;eye diseases;oxidative phosphorylation;pericytes;retina;Warburg effect;
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and ...
Leto:
2024
Vir:
Nacionalni inštitut za biologijo (NIB)