Št. zadetkov: 77
Pregledni znanstveni članek
Oznake:
mezoteliom;kemoterapija;imunoterapija;genska terapija;mesothelioma;chemotherapy;immunotherapy;gene therapy;
Mesothelioma is a rare tumor, frequently associated with asbestos exposure, arising from pleura and peritoneum. Traditionally, diagnosis and treatment have been difficult in a clinical setting. The treatment is based on a trimodal approach involving surgery, chemotherapy, and radiotherapy. The intro ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
diabetes mellitus tipa 2;debelost;agonisti receptorjev GLP-1;type 2 diabetes mellitus;obesity;GLP‐1 receptor agonists;
Glucagon-like peptide-1 (GLP-1) receptor agonists are a new class of antihyperglycemic drugs that enhance appropriate pancreatic β-cell secretion, pancreatic α-cell (glucagon) suppression, decrease liver glucose production, increase satiety through their action on the central nervous system, slow ga ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinsonova bolezen;motorični zapleti;vizualne halucinacije;Parkinson’s disease;motor complications;visual hallucinations;
The serotonergic system is important in Parkinson’s disease (PD) pathogenesis as it can take over dopamine production after a large portion of dopaminergic neurons is lost through neurodegeneration. The aim of this study was to evaluate the effect of genetic variability of serotonergic genes on the ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
COVID-19;neurodegeneration;Alzheimer’s disease;
Introduction: Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with neurological symptoms in COVID-19 patients and neurodegenerative seq ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
tramadol;genetski polimorfizmi;CYP2D6;UGT2B7;ABCC2;ABCB1;neželeni učinki;
Tramadol je centralno delujoč opioidni analgetik za lajšanje akutnih in kroničnih bolečin. Encimi CYP2D6, UGT2B7, ABCB1 in ABCC2 so ključni za presnovo in transport tramadola. Polimorfizmi v genih za te encime bi lahko vplivali na farmakokinetiko tramadola in s tem na odgovor na zdravljenje. Namen r ...
Leto:
2019
Vir:
Biotehniška fakulteta (UL BF)
Magistrsko delo
Oznake:
genotipizacija;genetska variabilnost;OPRM1;MIR23B;MIR107;tramadol;lajšanje bolečine;neželeni učinki;
Opioidni receptor mu, ki ga kodira OPRM1, je ključen za protibolečinsko delovanje opioidnih zdravil. Je tarča tramadola, ki spada med centralno delujoče opioidne analgetike za lajšanje zmernih do močnih akutnih in kroničnih bolečin. Genetski polimorfizmi OPRM1 in genov za miRNA lahko zaradi spremenj ...
Leto:
2021
Vir:
Biotehniška fakulteta (UL BF)
Izvirni znanstveni članek
Oznake:
operacija raka na dojki;zdravljenje bolečine;tramadol;
Background. Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its anal-gesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miR ...
Leto:
2023
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)
Oznake:
genetika;geni;polimorfizem;genetski polimorfizem;farmakogenetika;zdravila;presnova;
Background It is estimated that genetic factors account for 15-30% of variability in drug response, however for some drugs this may be the major determinantin drug response. Pharmacogenetics aims to identifygenetic sources of variability in response to drugs by studyinggenetic variations caffecting ...
Leto:
2007
Vir:
dLib.si Digitalna knjižnica Slovenije
Video in druga učna gradiva
Oznake:
medicine
Leto:
2014
Vir:
videolectures.net
Diplomsko delo
Oznake:
serotoninska pot;genetske spremembe;izražanje genov;
Shizofrenija je kompleksna bolezen z močno negativnimi posledicami za obolele in družbo, zato sta učinkovita diagnostika in zdravljenje posebnega pomena. Vendar pa je zaradi pomanjkanja znanja o molekularnih mehanizmih shizofrenije trenutno nemogoče napovedati odziv na zdravljenje. Za razumevanje mo ...
Leto:
2018
Vir:
Biotehniška fakulteta (UL BF)