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Št. zadetkov: 2
Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease
Urban Košak, Damijan Knez, Svit Ferjančič Benetik, Peter Mastnak-Sokolov, Anja Pišlar, Selena Horvat, Jure Stojan, Bingbing Lv, Weiting Zhang, Yuanyuan Wang, Stanislav Gobec
Izvirni znanstveni članek
Oznake: chiral switch;resolution of enantiomers;Alzheimer's disease;butyrylcholinesterase;enzyme inhibitors;
Butyrylcholinesterase (BChE) is a viable drug target to alleviate the symptoms of Alzheimer's disease (AD). We recently developed and biologically evaluated racemic N-benzylpiperidine-based naphthalene-2-sulfonamide 2, a nanomolar BChE inhibitor with procognitive effects. To optimize it, we performe ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer’s disease
Anže Meden, Neža Žnidaršič, Damijan Knez, Yuanyuan Wang, Ziwei Xu, Huajing Yang, Weiting Zhang, Anja Hafner, Andrej Perdih, Simona Kranjc, Neža Grgurevič, Stane Pajk, Haopeng Sun, Stanislav Gobec
Izvirni znanstveni članek
Oznake: pleiotropic prodrug;Alzheimer’s disease;butyrylcholinesterase;α2A adrenoreceptor;disease-modifying treatment;N-heterocyclic ureas;carbamates;neurodegenerative diseases;
The inherent complexity of Alzheimer’s disease (AD) and failed clinical trials have spiked the interest in multifunctional ligands that target at least two key disease-associated macromolecules in AD pathology. Here we present a focused series of pleiotropic N-carbamoylazole prodrugs with dual mecha ...
Leto: 2025 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 2
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