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Št. zadetkov: 3
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer’s disease
Anže Meden, Neža Žnidaršič, Damijan Knez, Yuanyuan Wang, Ziwei Xu, Huajing Yang, Weiting Zhang, Anja Hafner, Andrej Perdih, Simona Kranjc, Neža Grgurevič, Stane Pajk, Haopeng Sun, Stanislav Gobec
Izvirni znanstveni članek
Oznake: pleiotropic prodrug;Alzheimer’s disease;butyrylcholinesterase;α2A adrenoreceptor;disease-modifying treatment;N-heterocyclic ureas;carbamates;neurodegenerative diseases;
The inherent complexity of Alzheimer’s disease (AD) and failed clinical trials have spiked the interest in multifunctional ligands that target at least two key disease-associated macromolecules in AD pathology. Here we present a focused series of pleiotropic N-carbamoylazole prodrugs with dual mecha ...
Leto: 2025 Vir: Veterinarska fakulteta (UL VF)
Asymmetric Transitivity Preserving Graph Embedding
Ziwei Zhang
Video in druga učna gradiva
Oznake: computer science;data science
Graph embedding algorithms embed a graph into a vector space where the structure and the inherent properties of the graph are preserved. The existing graph embedding methods cannot preserve the asymmetric transitivity well, which is a critical property of directed graphs. Asymmetric transitivity dep ...
Leto: 2016 Vir: videolectures.net
Semantic Image Segmentation via Deep Parsing Network
Xiaoxiao Li , Ziwei Liu
Video in druga učna gradiva
Oznake: computer science;computer vision
This paper addresses semantic image segmentation by incorporating rich information into Markov Random Field (MRF), including high-order relations and mixture of label contexts. Unlike previous works that optimized MRFs using iterative algorithm, we solve MRF by proposing a Convolutional Neural Netwo ...
Leto: 2015 Vir: videolectures.net
Št. zadetkov: 3
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