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Št. zadetkov: 33
Pregledni znanstveni članek
Oznake: dendritične celice;protitumorska cepiva;rak;imunoterapija;celice T;
Odkritje s tumorjem-povezanih antigenov, ki jih bodisi selektivno ali preferečno izražajo tumorji, s sočasnim poglobljenim znanjem ključne vloge dendritičnih celic (DC) v imunskem sistemu, je postavilo temelje za pričetek imunoterapije raka na osnovi DC. 29. aprila 2010 je FDA odobrila Provenge (sip ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Kratki znanstveni prispevek
Oznake: COX2;PGE2;human;cancer;myeloid-derived suppressor cells;immune dysfunction;immunotherapy;transplantation;
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functio ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: cancer;COX2;dentritic cells;immune dysfunction;human;imunotherapy;myeloid-derived suppressor cells;PGe2;transplantation;
Myeloid-derived suppressor cells (MDSCs) are natural immunosuppressive cells and endogenous inhibitors of the immune system. We describe a simple and clinically compatible method of generating large numbers of MDSCs using the cultures of peripheral blood-isolated monocytes supplemented with prostagl ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Diplomsko delo
Oznake: Th17 celice;CD4+ celice;imunski sistem;imunski odziv;prostaglandin E2;supresorske celice;
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Diplomsko delo
Oznake: dendritične celice;CD8+ celice;adhezija DC;citokini;imunski odziv;T-celični receptorji;
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Objavljeni znanstveni prispevek na konferenci
Oznake:
T cells migrate through restrictive barriers in a protease-independent, amoeboid fashion that is characterized by morphological cell polarization. Theinteraction of cysteine-dependent carboxypeptidase cathepsin X with 2 integrin LFA-1 (lymphocyte function associated antigen 1) induces T-cell morphol ...
Leto: 2009 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
Background Generation of plasmin is a characteristic of tumor cells, promoting the degradation of extracellular matrix, tumor progression and metastasis. The process is accelerated if plasminogen and plasminogen activator are bound to their cell surface receptors. Results In this study weshow that t ...
Leto: 2009 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: imunsko modeliranje;regulatorne T celice;resveratrol;toleranca;dendritične celice;
Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-in ...
Leto: 2010 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: gamma-1-sintropin;gama enolaze;katepsin X;nevrotropična aktivnost;
Syntrophins are scaffold proteins that can bind several signaling molecules and localize them to the plasma membrane. We demonstrate here that in neuroblastoma SH-SY5Y cells, brain-specific gamma1-syntrophin binds the neurotrophic factor gamma-enolase through its PDZ domain, and translocates it to t ...
Leto: 2010 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: katepsin X;LFA-1;T-celice;
The adhesion molecule lymphocyte function-associated antigen (LFA)-1 plays a key role in immune surveillance and response. Its conformation is spatially and temporally regulated, enabling adhesion and deadhesion during T-cell migration. LFA-1 adhesion to its major ligand intercellular adhesion molec ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 33
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