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Št. zadetkov: 8
Funkcionalna opredelitev zarodnih različic neznanega kliničnega pomena z analizo mRNA pri bolnikih ogroženih z dednimi oblikami raka
Vita Šetrajčič Dragoš, Srdjan Novaković
Doktorska disertacija
Oznake: genetika;mRNA;sekvenciranje naslednje generacije;sekvenciranje RNA;različice neznanega kliničnega pomena;dedne oblike raka;doktorska disertacija;
Genetske različice lahko povzročijo nepravilno prepoznavo spojitvenih mest med procesom izrezovanja intronov in spajanja eksonov, ki ga izvrši izrezovalno-povezovalni kompleks med formiranjem zrele mRNA. Posledica tega je spremenjena mRNA molekula, kar je lahko vzrok za nastanek genetskih sindromov. ...
Leto: 2023 Vir: Biotehniška fakulteta (UL BF)
Mutational burden, MHC-I expression and immune infiltration as limiting factors for in situ vaccination by TNF[alfa] and IL-12 gene electrotransfer
Urška Kamenšek, Katja Uršič, Boštjan Markelc, Maja Čemažar, Vita Šetrajčič Dragoš, Gregor Serša
Izvirni znanstveni članek
Oznake: cepljenje in situ;genski elektrotransfer;interlevkin 12;dejavnik tumorske nekroze [alfa];in situ vaccination;gene electrotransfer;interleukin 12;tumor necrosis factor [alfa];
In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the therapy-killed tumor cells. We recently proposed using intratumoral gene electrotransfer for concomitant trans ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
New approach for detection of normal alternative splicing events and aberrant spliceogenic transcripts with long-range PCR and deep RNA sequencing
Vita Šetrajčič Dragoš, Vida Stegel, Ana Blatnik, Gašper Klančar, Mateja Krajc, Srdjan Novaković
Izvirni znanstveni članek
Oznake: sekvencioniranje RNA;variante DNA;spajanje;RNA sequencing;DNA variant;splicing;
RNA sequencing is a promising technique for detecting normal and aberrant RNA isoforms. Here, we present a new single-gene, straightforward 1-day hands-on protocol for detection of splicing alterations with deep RNA sequencing from blood. We have validated our method%s accuracy by detecting previous ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Molekularna diagnostika v onkologiji
Srdjan Novaković, Petra Cerkovnik, Vida Stegel, Ana Blatnik, Vita Šetrajčič Dragoš, Matic Leban
Ni določena
Oznake: onkologija;genetika;mutacije;sporadični rak;dejavniki tveganja;genetsko testiranje;Onkologija;Dedni rak;Molekularna diagnostika;
Molekularna diagnostika v onkologiji
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Identification of spliceogenic variants beyond canonical GT-AG splice sites in hereditary cancer genes
Vita Šetrajčič Dragoš, Ksenija Strojnik, Gašper Klančar, Petra Cerkovnik, Vida Stegel, Ana Blatnik, Marta Banjac, Mateja Krajc, Srdjan Novaković
Izvirni znanstveni članek
Oznake: dedni raki;sekvencioniranje RNA;spajanje;geni;hereditary cancer;RNA sequencing;spliceogenic;
Pathogenic/likely pathogenic variants in susceptibility genes that interrupt RNA splicing are a well-documented mechanism of hereditary cancer syndromes development. However, if RNA studies are not performed, most of the variants beyond the canonical GT-AG splice site are characterized as variants o ...
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome
Ana Blatnik, Domen Ribnikar, Vita Šetrajčič Dragoš, Srdjan Novaković, Vida Stegel, Biljana Grčar-Kuzmanov, Nina Boc, Barbara Perić, Petra Cerkovnik, Gašper Klančar, Mateja Krajc
Izvirni znanstveni članek
Oznake: BAP1;rak dojke;dedni raki;imunoterapija;breast cancer;hereditary cancer syndromes;immunotherapy;
BAP1 cancer syndrome is a rare and highly penetrant hereditary cancer predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) and cutaneous melanoma are considered BAP1 cancer syndrome core cancers, whereas association with breast cancer has previously been suggested but not confirm ...
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Real-world data on detection of germline and somatic pathogenic/likely pathogenic variants in BRCA1/2 and other susceptibility genes in ovarian cancer patients using next generation sequencing
Vida Stegel, Ana Blatnik, Erik Škof, Vita Šetrajčič Dragoš, Mateja Krajc, Brigita Gregorčič, Petra Cerkovnik, Ksenija Strojnik, Gašper Klančar, Marta Banjac, Janez Žgajnar, Maja Ravnik-Oblak, Srdjan Novaković
Izvirni znanstveni članek
Oznake: BRCA;rak jajčnikov;genotip tumorja;HBOC;ovarian cancer;tumor genotyping;
Detection of germline and somatic pathogenic/likely pathogenic variants (PV/LPV) in BRCA genes is at the moment a prerequisite for use of PARP inhibitors in different treatment settings of different tumors. The aim of our study was to determine the most appropriate testing workflow in epithelial ova ...
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Znanje kot faktor gospodarskega razvoja
Eva Šetrajčič Dragoš, Tjaša Redek
Diplomsko delo
Oznake: Koreja;ekonomski razvoj;ekonomska rast;znanje;človeški kapital;konkurenčne prednosti;analiza;
Znanje kot faktor gospodarskega razvoja
Leto: 2011 Vir: Ekonomska fakulteta (UL EF)
Št. zadetkov: 8
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