pathophysiological mechanisms and therapeutic perspectives
Chiedozie Kenneth Ugwoke (Author), Erika Cvetko (Author), Nejc Umek (Author)

Abstract

Obesity is a worrisomely escalating public health problem globally and one of the leading causes of morbidity and mortality from noncommunicable disease. The epidemiological link between obesity and a broad spectrum of cardiometabolic disorders has been well documented; however, the underlying pathophysiological mechanisms are only partially understood, and effective treatment options remain scarce. Given its critical role in glucose metabolism, skeletal muscle has increasingly become a focus of attention in understanding the mechanisms of impaired insulin function in obesity and the associated metabolic sequalae. We examined the current evidence on the relationship between microvascular dysfunction and insulin resistance in obesity. A growing body of evidence suggest an intimate and reciprocal relationship between skeletal muscle microvascular and glucometabolic physiology. The obesity phenotype is characterized by structural and functional changes in the skeletal muscle microcirculation which contribute to insulin dysfunction and disturbed glucose homeostasis. Several interconnected etiologic molecular mechanisms have been suggested, including endothelial dysfunction by several factors, extracellular matrix remodelling, and induction of oxidative stress and the immunoinflammatory phenotype. We further correlated currently available pharmacological agents that have deductive therapeutic relevance to the explored pathophysiological mechanisms, highlighting a potential clinical perspective in obesity treatment.

Keywords

microvascular dysfunction;insulin resistance;obesity treatment;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 611
COBISS: 93446147 Link will open in a new window
ISSN: 1422-0067
Views: 69
Downloads: 31
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: mikrovaskularna disfunkcija;odpornost proti insulinu;zdravljenje debelosti;
Type (COBISS): Article
Pages: str. 1-22
Volume: ǂVol. ǂ23
Issue: ǂiss. ǂ2
Chronology: 2022
DOI: 10.3390/ijms23020847
ID: 15504159
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