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Št. zadetkov: 6
Optimizacija sinteze potencialnih 1,4-benzooksazinskih modulatorjev vitronektinskega receptorja
Aleš Žula, Marija Sollner Dolenc, Žiga Jakopin
Diplomsko delo
Oznake: integrini;integrinski receptorji;antagonisti vitronektinskega receptorja;sinteza;metode;
Optimizacija sinteze potencialnih 1,4-benzooksazinskih modulatorjev vitronektinskega receptorja
Leto: 2009 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis and evaluation of spumigin analogues library with thrombin inhibitory activity
Aleš Žula, Izabela Będziak, Danijel Kikelj, Janez Ilaš
Izvirni znanstveni članek
Oznake: biokemija;morski proizvodi;naravni peptidi;inhibicija trombina;marine products;natural peptides;peptidomimetics;thrombin inhibition;
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the D-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S ...
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability
Blaž Lebar, Mitja Zidar, Janez Mravljak, Roman Šink, Aleš Žula, Stane Pajk
Izvirni znanstveni članek
Oznake: biopharmaceuticals;buffer;stress;aggregates;alternative buffers;stability;
The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer composition plays a pivotal role. However, conventional buffers l ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek, Goran Miličić, Aleš Žula, Stanislav Gobec
Izvirni znanstveni članek
Oznake: viscosity;protein formulations;biopharmaceuticals;viscosity-reducing agents;computational screening;
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Action of clathrodin and analogues on voltage-gated sodium channels
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David J. Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Izvirni znanstveni članek
Oznake: oroidin;hymenidin;clathrodin;voltage-gated sodium channels;sodium channel modulator;sponge;
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could representan interesting lead compound. Therefore, clathrodin was reinvestigated for its ...
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues
Nace Zidar, Sofia Montalvão, Žiga Hodnik, Dorota A. Nawrot, Aleš Žula, Janez Ilaš, Danijel Kikelj, Päivi Tammela, Lucija Peterlin-Mašič
Izvirni znanstveni članek
Oznake: marine alkaloid;Agelas;clathrodin;oroidin;pyrrole-2-aminoimidazole;antibacterial;
Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from s ...
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 6
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