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Št. zadetkov: 7
Monovalent ions aid catalysis of two-metal-ion dependent RNA editors
Jure Borišek, Jana Aupič, Alessandra Magistrato
Pregledni znanstveni članek
Oznake: biokemija;RNK;nukleinske kisline;kataliza;geni;terapevtske strategije;two-metal-ion catalytic mechanism;monovalent metal ion;phosphodiester bond cleavage;spliceosome;ribonuclease;
The cleavage and formation of phosphodiester bonds in nucleic acids is performed by diverse cellular machineries ranging from small protein enzymes to large complexes composed of proteins and/or RNA strands. While it has long been believed that these processes depend solely on a two-metal-ion mechan ...
Leto: 2026 Vir: Kemijski inštitut (KI)
ǂThe ǂconformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter
Pavel Janoš, Jana Aupič, Sharon Ruthstein, Alessandra Magistrato
Izvirni znanstveni članek
Oznake: Copper;membrane transporter;molecular dynamics;QM/MM;free energy;
Copper is a trace element vital to many cellular functions. Yet its abnormal levels are toxic to cells, provoking a variety of severe diseases. The high affinity copper transporter 1 (CTR1), being the main in-cell copper [Cu(I)] entry route, tightly regulates its cellular uptake via a still elusive ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Intrinsically disordered ectodomain modulates ion permeation through a metal transporter
Jana Aupič, Fabio Lapenta, Pavel Janoš, Alessandra Magistrato
Izvirni znanstveni članek
Oznake: ion channels and transporters;intrinsically disordered regions;molecular dynamics;function regulation;
Intrinsically disordered ectodomain modulates ion permeation through a metal transporter
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion
Gulshan Walke, Jana Aupič, Hadeel Kashoua, Pavel Janoš, Shelly Meron, Yulia Shenberger, Zena Qasem, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Izvirni znanstveni članek
Oznake: Ctr1;copper;EPR;molecular dynamics;
Abnormal cellular copper levels have been clearly implicated in genetic diseases, cancer, and neurodegeneration. Ctr1, a high-affinity copper transporter, is a homotrimeric integral membrane protein that provides the main route for cellular copper uptake. Together with a sophisticated copper transpo ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Disrupting Cu trafficking as a potential therapy for cancer
Zena Qasem, Matic Pavlin, Ida Ritacco, Matan Y. Avivi, Shelly Meron, Melanie Hirsch, Yulia Shenberger, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Izvirni znanstveni članek
Oznake: biokemija;biološki procesi;baker;rakave celice;
Leto: 2022 Vir: Kemijski inštitut (KI)
Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides
Nika Žibrat, Andreja Habič, Katerina Naumoska, Tina Snoj, Jana Aupič, Vesna Glavnik, Alen Albreht, Mojca Mally, Jure Derganc, Peter Greimel, Alessandra Magistrato, Gregor Anderluh
Izvirni znanstveni članek
Oznake: biokemija;rastline;patogeni;simulacije;molekulske dinamike;
Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
ǂA ǂstructural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels
Luisa M. R. Napolitano, Ina Bisha, Matteo De March, Arin Marchesi, Manuel Arcangeletti, Nicola Demitri, Monica Mazzolini, Alex Rodriguez, Alessandra Magistrato, Silvia Onesti
Izvirni znanstveni članek
Oznake: CNG channels;pore flexibility;X-ray crystallography;MD simulations;
A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels
Leto: 2015 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 7
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