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Št. zadetkov: 3
ǂThe ǂconformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter
Pavel Janoš, Jana Aupič, Sharon Ruthstein, Alessandra Magistrato
Izvirni znanstveni članek
Oznake: Copper;membrane transporter;molecular dynamics;QM/MM;free energy;
Copper is a trace element vital to many cellular functions. Yet its abnormal levels are toxic to cells, provoking a variety of severe diseases. The high affinity copper transporter 1 (CTR1), being the main in-cell copper [Cu(I)] entry route, tightly regulates its cellular uptake via a still elusive ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Intrinsically disordered ectodomain modulates ion permeation through a metal transporter
Jana Aupič, Fabio Lapenta, Pavel Janoš, Alessandra Magistrato
Izvirni znanstveni članek
Oznake: ion channels and transporters;intrinsically disordered regions;molecular dynamics;function regulation;
Intrinsically disordered ectodomain modulates ion permeation through a metal transporter
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion
Gulshan Walke, Jana Aupič, Hadeel Kashoua, Pavel Janoš, Shelly Meron, Yulia Shenberger, Zena Qasem, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Izvirni znanstveni članek
Oznake: Ctr1;copper;EPR;molecular dynamics;
Abnormal cellular copper levels have been clearly implicated in genetic diseases, cancer, and neurodegeneration. Ctr1, a high-affinity copper transporter, is a homotrimeric integral membrane protein that provides the main route for cellular copper uptake. Together with a sophisticated copper transpo ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 3
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