Št. zadetkov: 11
Izvirni znanstveni članek
Oznake:
paraoksonaza 1;dihidrokumarin;krivulje napredka;paraoxonase 1;dihydrocoumarin;progress curves;
Several approaches for determining an enzyme’s kinetic parameter Km (Michaelis constant) from progress curves have been developed in recent decades. In the present article, we compare different approaches on a set of experimental measurements of lactonase activity of paraoxonase 1 (PON1): (1) a diff ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
Alzheimer's disease;butyrylcholinesterase;cholinesterase inhibitors;genetic variants;
Butyrylcholinesterase (BChE), once regarded as a redundant cholinesterase, has emerged as an important modulator of Alzheimer's disease (AD). Unlike acetylcholinesterase (AChE), which declines during disease progression, BChE activity is preserved or elevated in the AD brain and becomes the predomin ...
Leto:
2026
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinsonova bolezen;kognitivne motnje;paraoksonaza 1;Parkinson disease;cognitive impairment;paraoxonase 1;
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), which often progresses to PD dementia. PD patients with and without dementia may differ in certain biochemical parameters, which could thus be used as biomarkers for PD dementia. The enzyme paraoxonase 1 (PON1) has previ ...
Leto:
2023
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Doktorska disertacija
Oznake:
paraoksonaza 1;Alzheimerjeva demenca;Parkinsonova bolezen;kognitivni upad;encimska kinetika;integrirana Michaelis-Mentenina enačba;laktonazna aktivnost;arilesterazna aktivnost;paraoksonazna aktivnost;
Ozadje: Encim paraoksonaza 1 (PON1) je prisoten v krvni plazmi, vezan na delce lipoproteinov visoke gostote (HDL) in ima antioksidativno vlogo. Njegovi fiziološki substrati niso dobro znani. Aktivnost PON1 v plazmi in polimorfizme (SNP) gena PON1 so preučevali pri blagi kognitivni motnji (BKM), pri ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
paraoxonase;lactonase;oxidative stress;
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascul ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
rekombinantna paraoksonaza 1;paraokson;2-hidroksikinolin;stabilnost proteinov;encimska aktivnost;magistrska dela;
Serumske paraoksonaze (PON) so proteinska družina pri sesalcih, ki jih sestavljajo encimi PON1, PON2 in PON3. Najbolj raziskan član družine je encim paraoksonaza 1 (PON1), ki ima laktonazno, arilesterazno in paraoksonazno aktivnost. Pomembno vpliva na preprečevanje srčno-žilnih in nevrodegenerativn ...
Leto:
2022
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
paraoxonase-1;arylesterase activity;reversible inhibition;
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostig ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Intramolecular sensitization;structure of a conjugate;paraoxonase 1;
Paraoxonase 1 (PON1) is a Ca2+-dependent enzyme involved in oxidative stress processes and is widely studied for its protective roles in various diseases. Intermolecular sensitization of lanthanide ions was implemented by replacing Ca2+ ions from the recombinant PON1 (rePON1) catalytic site in the p ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Primož Strojan,
Gaber Plavc,
Marko Kokalj,
Goran Mitrović,
Olga Blatnik,
Luka Ležaič,
Aljaž Sočan,
Aljoša Bavec,
Nataša Tešić,
Katrina Pretnar-Hartman,
Urban Švajger
Izvirni znanstveni članek
Oznake:
oropharyngeal cancer;xerostomia;mesenchymal stromal stem cells;
Background: Xerostomia is a common side effect of radiotherapy in patients with head and neck tumors that negatively affects quality of life. There is no known effective standard treatment for xerostomia. Here, we present the study protocol used to evaluate the safety and preliminary efficacy of all ...
Leto:
2023
Vir:
Onkološki inštitut Ljubljana (OI)
Primož Strojan,
Marko Kokalj,
Gaber Plavc,
Goran Mitrović,
Olga Blatnik,
Luka Ležaič,
Aljaž Sočan,
Aljoša Bavec,
Nataša Tešić,
Katrina Pretnar-Hartman,
Urban Švajger
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake:
obsevanje;radioterapija;onkologija;
Leto:
2025
Vir:
Onkološki inštitut Ljubljana (OI)