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Št. zadetkov: 2
Selective DNA gyrase inhibitors
Tihomir Tomašić, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant
Izvirni znanstveni članek
Oznake: antibacterial;ATP-competitive;DNA gyrase;Hsp90;pharmacophore model;topoisomerase II[alpha];target activity profiling;
Background: DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selecti ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
New class of Hsp90 C-terminal domain inhibitors with anti-tumor properties against triple-negative breast cancer
Živa Zajec, Jaka Dernovšek, Jernej Cingl, Iza Ogris, Marius Gedgaudas, Asta Zubrienė, Ana Mitrović, Simona Golič Grdadolnik, Martina Gobec, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: analize;zaviralci;fenili;rak dojk;
Triple-negative breast cancer (TNBC) remains a treatment challenge and requires innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has emerged as a promising therapeutic target. In this study, we present the optimization of the Hsp90 C-terminal domain (CTD) inhibi ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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