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Št. zadetkov: 5
Interregional Innovation Policy in South East Europe: Past Experiences and Prospects for the Future
Christian Hartmann
Video in druga učna gradiva
Oznake: technology;innovation
Leto: 2009 Vir: videolectures.net
Technik
Elke Hartmann, Elke Hartmann, Christian Hein, Christian Hein, Elisabeth Klaus, Rolf Münchow, Martina Schramm, Wolfgang Stenzel, Volker Torgau, Bernd Wöhlbrandt, Marko Marhl, Branko Kaučič
Enciklopedija, slovar, leksikon, priročnik, atlas, zemljevid
Oznake: tehnika;pouk;didaktika;priročniki;ne zaključna dela;
Technik
Leto: 2001 Vir: Pedagoška fakulteta (UM PEF)
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach
Izvirni znanstveni članek
Oznake: the Petasis borono-Mannich reaction;Strecker synthesis;CRBN ligands;
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The high-affinity ligands were used to assemble prototyp ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Fluorinated aminopiperidones as non-glutarimide thalidomide analogs
Boštjan Adamlje, Tihomir Tomašić, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Izidor Sosič, Izidor Sosič, Andrej Emanuel Cotman, Andrej Emanuel Cotman
Izvirni znanstveni članek
Oznake: bioisosterism;diastereoselectivity;drug design;fluorine;PROTAC;
The glutarimide fragment is a key pharmacophore in cereblon-binding immunomodulatory drugs and proteolysis-targeting chimeras, yet exploration of non-glutarimide scaffolds remains limited. Here, we report the design, synthesis, and evaluation of fluorinated aminopiperidones as three-dimensional, non ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Direct tumor-adipocyte contact as a prognostic biomarker in resected pancreatic ductal adenocarcinoma
Michael Günther, Konstantin Bräutigam, Martin Wartenberg, Muhammed D. Arslan, Robert Sucher, Mohamed El-Mahrouk, Jens Neumann, Przemyslaw Grochowski, Anna S. Wenning, Beat Gloor, Berna Dornieden, Robert Grützmann, Christian Pilarsky, Arndt Hartmann, Markus Eckstein, Bruno Märkl, Christian Matek, Kristijan Skok, Steffen Ormanns, Nic G. Reitsam
Izvirni znanstveni članek
Oznake: adenocarcinoma;adipose tissue;multicenter;PDAC;pancreas;prognosis;SARIFA;tumor microenvironment;tumor-adipocyte-contact;
Background: Direct tumor-adipocyte contact (TAC), also referred to as Stroma AReactive Invasion Front Areas (SARIFA), is an emerging histomorphologic biomarker, defined by histologically visible direct tumor-adipocyte interaction. Its prognostic relevance in pancreatic ductal adenocarcinoma (PDAC) h ...
Leto: 2026 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 5
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