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Št. zadetkov: 4
Overview of the assays to probe O-linked β-N-acetylglucosamine transferase binding and activity
Cyril Balsollier, Roland J. Pieters, Marko Anderluh
Pregledni znanstveni članek
Oznake: GT;GlcNAcylation;O-GlcNAc Transferase;bioassay;OGT inhibitor;
O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches the GlcNAc residue to ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Uporaba bioloških in računalniških orodij za načrtovanje, testiranje in sintezo novih zaviralcev β-N-acetilglukozaminil transferaze
Cyril Balsollier, Marko Anderluh, Roland J. Pieters
Doktorska disertacija
Oznake: OGT;O-GlcNAcylation;medicinska kemija;računalniška kemija;biološki preskusi;biokemija;organska kemija;
O-GlcNAcilacija je posttranslacijska modifikacija, ki se v celici pojavlja na serinskih in treoninskih ostankih beljakovin. Te aminokisline se modificirajo na svoji hidroksilni funkciji s priključitvijo ß-N-acetilglukozaminskega dela. To uravnavata dva encima O-GlcNAc transferaza (OGT), ki dodaja Gl ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
New quinolinone O-GlcNAc transferase inhibitors based on fragment growth
Matjaž Weiss, Elena Maria Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašić, Roland J. Pieters, Martina Gobec, Marko Anderluh
Izvirni znanstveni članek
Oznake: O-GlcNAc;O-GlcNAc transferase;protein glycosylation;fragments growth;molecular docking;
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of a new drug-like series of OGT inhibitors by virtual screening
Elena Maria Loi, Tihomir Tomašić, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Izvirni znanstveni članek
Oznake: O-GlcNAc transferase;OGT inhibitors;virtual screening;
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. Howeve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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