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Št. zadetkov: 4
Pregledni znanstveni članek
Oznake: GT;GlcNAcylation;O-GlcNAc Transferase;bioassay;OGT inhibitor;
O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches the GlcNAc residue to ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Doktorska disertacija
Oznake: OGT;O-GlcNAcylation;medicinska kemija;računalniška kemija;biološki preskusi;biokemija;organska kemija;
O-GlcNAcilacija je posttranslacijska modifikacija, ki se v celici pojavlja na serinskih in treoninskih ostankih beljakovin. Te aminokisline se modificirajo na svoji hidroksilni funkciji s priključitvijo ß-N-acetilglukozaminskega dela. To uravnavata dva encima O-GlcNAc transferaza (OGT), ki dodaja Gl ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: O-GlcNAc;O-GlcNAc transferase;protein glycosylation;fragments growth;molecular docking;
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: O-GlcNAc transferase;OGT inhibitors;virtual screening;
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. Howeve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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