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Št. zadetkov: 15
Sinteza iminosladkornih zaviralcev glukocerebrozidaze beta
Jakob Rihter, Marko Anderluh, Roland J. Pieters
Magistrsko delo
Oznake:
Synthesis of iminosugar beta glucocerebrosidase inhibitors
Leto: 2017 Vir: Fakulteta za farmacijo (UL FFA)
Guanidinium iminosugar derivatives as precursors to Beta-glucocerebrosidase inhibitors
Luka Šrot, Marko Anderluh, Roland J. Pieters
Magistrsko delo
Oznake:
Guanidinium iminosugar derivatives as precursors to Beta-glucocerebrosidase inhibitors
Leto: 2017 Vir: Fakulteta za farmacijo (UL FFA)
Sinteza gvanidinskih iminosladkorjev kot prekurzorjev za nove selektivne zaviralce beta - glukozidaze
Maša Rugel, Marko Anderluh, Roland J. Pieters
Magistrsko delo
Oznake:
Synthesis of guanidinlated iminosugars as precursors for new selective beta - glucosidase inhibitors
Leto: 2017 Vir: Fakulteta za farmacijo (UL FFA)
Overview of the assays to probe O-linked β-N-acetylglucosamine transferase binding and activity
Cyril Balsollier, Roland J. Pieters, Marko Anderluh
Pregledni znanstveni članek
Oznake: GT;GlcNAcylation;O-GlcNAc Transferase;bioassay;OGT inhibitor;
O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches the GlcNAc residue to ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Uporaba bioloških in računalniških orodij za načrtovanje, testiranje in sintezo novih zaviralcev β-N-acetilglukozaminil transferaze
Cyril Balsollier, Marko Anderluh, Roland J. Pieters
Doktorska disertacija
Oznake: OGT;O-GlcNAcylation;medicinska kemija;računalniška kemija;biološki preskusi;biokemija;organska kemija;
O-GlcNAcilacija je posttranslacijska modifikacija, ki se v celici pojavlja na serinskih in treoninskih ostankih beljakovin. Te aminokisline se modificirajo na svoji hidroksilni funkciji s priključitvijo ß-N-acetilglukozaminskega dela. To uravnavata dva encima O-GlcNAc transferaza (OGT), ki dodaja Gl ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Strukturno podprto načrtovanje, sinteza in biološko vrednotenje novih zaviralcev O-β-N-acetilglukozaminil transferaze
Elena Maria Loi, Marko Anderluh, Roland J. Pieters
Doktorska disertacija
Oznake: O-GlcNAcylation;OGT;OGA;OGT inhibitors;posttranslational modifications;computational drug design;virtual screening;ester hydrolysis;metabolic stability.;
Thousands of nuclear and cytosolic proteins are subjected to post-translational modification at serine or threonine residues by O-linked ß-N-acetylglucosamine (O-GlcNAc). This unique type of glycosylation, known as O-GlcNAcylation, does not result in complex glycans but is rather cycled on and off p ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Structure-based design, synthesis and biological evaluation of novel O-β-N-acetylglucosaminyltransferase inhibitors
Elena Maria Loi, Marko Anderluh, Roland J. Pieters
Doktorska disertacija
Oznake: O-GlcNAcylation;OGT;OGA;OGT inhibitors;posttranslational;modifications;computational drug design;virtual screening;ester hydrolysis;metabolic stability;
Thousands of nuclear and cytosolic proteins are subjected to post-translational modification at serine or threonine residues by O-linked ß-N-acetylglucosamine (O-GlcNAc). This unique type of glycosylation, known as O-GlcNAcylation, does not result in complex glycans but is rather cycled on and off p ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Intracellular hydrolysis of small-molecule O-linked N-acetylglucosamine transferase inhibitors differs among cells and is not required for its inhibition
Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašić, Roland J. Pieters, Marko Anderluh
Izvirni znanstveni članek
Oznake: ester hydrolysis;inhibitor;O-GlcNAc transferase;OGT inhibitor;
O-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. O-GlcNAc transferase (OGT) is the enzyme that catalyzes this reaction and represents a potentia ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
New quinolinone O-GlcNAc transferase inhibitors based on fragment growth
Matjaž Weiss, Elena Maria Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašić, Roland J. Pieters, Martina Gobec, Marko Anderluh
Izvirni znanstveni članek
Oznake: O-GlcNAc;O-GlcNAc transferase;protein glycosylation;fragments growth;molecular docking;
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of a new drug-like series of OGT inhibitors by virtual screening
Elena Maria Loi, Tihomir Tomašić, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Izvirni znanstveni članek
Oznake: O-GlcNAc transferase;OGT inhibitors;virtual screening;
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. Howeve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 15
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