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Št. zadetkov: 2
Simple HPLC-UV method for therapeutic drug monitoring of 12 antiepileptic drugs and their main metabolites in human plasma
Daniela Milosheska, Robert Roškar
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Oznake: antiepileptična zdravila;človeška plazma;terapevtsko spremljanje zdravil;validacija bioanalitskih metod;tekočinska kromatografija visoke ločljivosti;antiepileptic drugs;human plasma;therapeutic drug monitoring;bioanalytical method validation;high-performance liquid chromatography;
The objective of the present report was to develop and validate a simple, selective, and reproducible high-performance liquid chromatography method with UV detection suitable for routine therapeutic drug monitoring of the most commonly used antiepileptic drugs and some of their metabolites. Simple p ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
ǂAn ǂLC-MS/MS method for quantification of lamotrigine and its main metabolite in dried blood spots
Daniela Milosheska, Robert Roškar, Tomaž Vovk, Bogdan Lorber, Iztok Grabnar, Jurij Trontelj
Izvirni znanstveni članek
Oznake: posušena krvna lisa;lamotrigin;lamotrigin glukuronid;terapevtsko spremljanje zdravil;klinična validacija;učinek hematokrita;dried blood spot;lamotrigine;lamotrigine glucuronide;therapeutic drug monitoring;clinical validation;haematocrit effect;
Background: The antiepileptic drug lamotrigine (LTG) shows high pharmacokinetic variability due to genotype influence and concomitant use of glucuronidation inducers and inhibitors, both of which may be frequently taken by elderly patients. Our goal was to develop a reliable quantification method fo ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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