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Selective DNA gyrase inhibitors
Tihomir Tomašić, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant
Izvirni znanstveni članek
Oznake: antibacterial;ATP-competitive;DNA gyrase;Hsp90;pharmacophore model;topoisomerase II[alpha];target activity profiling;
Background: DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selecti ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
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