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Št. zadetkov: 2
Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham
Izvirni znanstveni članek
Oznake: Lyme arthritis;autoimmune diseases;infectious disease;
Background. Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of HLA-DR–presente ...
Leto: 2023 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling
Senka Ljubojevic-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Julia Schipke, Marlene Schmidt, Katharina-Maria Kling, Greta Therese Franke, Viktoria Herbst, Simon Sedej
Izvirni znanstveni članek
Oznake: autophagy;beta-adrenergic signalling;calcium;cardiomyocytes;mitochondria;
Aims: Autophagy protects against the development of cardiac hypertrophy and failure. While aberrant Ca2+ handling promotes myocardial remodelling and contributes to contractile dysfunction, the role of autophagy in maintaining Ca2+ homeostasis remains elusive. Here, we examined whether Atg5 deficien ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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