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Št. zadetkov: 2
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart
Mahmoud Abdellatif, Frank Madeo, Guido Kroemer, Simon Sedej
Kratki znanstveni prispevek
Oznake: heart failure;IGF1R;PI3K;human;insulin signaling;longevity;mitochondrial dysfunction;mouse;
Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-i ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity
Mahmoud Abdellatif, Viktoria Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J Hofer, Moydul Islam, Julia Voglhuber, Simon Sedej
Izvirni znanstveni članek
Oznake: aging;autophagy;cardiomyopathies;insulin-like growth factor 1;mitochondria;mouse;phosphatidylinositol 3-kinases;
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to assess ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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