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Št. zadetkov: 4
Rab3a is critical for trapping alpha-MSH granules in the high Ca2+-affinity pool by preventing constitutive exocytosis
Simon Sedej, Maša Skelin, Oliver Schlüter, Marjan Rupnik
Izvirni znanstveni članek
Oznake: melanotrophs;exocytosis;
Rab3a is a small GTPase of the Rab3 subfamily that acts during late stages of Ca2+-regulated exocytosis. Previous functional analysis in pituitary melanotrophs described Rab3a as a positive regulator of Ca2+-dependent exocytosis. However, the precise role of the Rab3a isoform on the kinetics and int ...
Leto: 2013 Vir: Medicinska fakulteta (UM MF)
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart
Mahmoud Abdellatif, Frank Madeo, Guido Kroemer, Simon Sedej
Kratki znanstveni prispevek
Oznake: heart failure;IGF1R;PI3K;human;insulin signaling;longevity;mitochondrial dysfunction;mouse;
Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-i ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity
Mahmoud Abdellatif, Viktoria Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J Hofer, Moydul Islam, Julia Voglhuber, Simon Sedej
Izvirni znanstveni članek
Oznake: aging;autophagy;cardiomyopathies;insulin-like growth factor 1;mitochondria;mouse;phosphatidylinositol 3-kinases;
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to assess ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Upravljanje z zalogami v trgovskem podjetju
Matej Sedej, Simon Čadež
Diplomsko delo
Oznake: trgovina;trgovinsko podjetje;poslovanje podjetja;uspešnost poslovanja;zaloge;upravljanje;modeli;case study;Divizija veleprodaja;
Upravljanje z zalogami v trgovskem podjetju
Leto: 2005 Vir: Ekonomska fakulteta (UL EF)
Št. zadetkov: 4
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