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Discovery of a new drug-like series of OGT inhibitors by virtual screening
Elena Maria Loi, Tihomir Tomašić, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Izvirni znanstveni članek
Oznake: O-GlcNAc transferase;OGT inhibitors;virtual screening;
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. Howeve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
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