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Št. zadetkov: 10
Upravljanje prožnosti elektroenergetskega omrežja z uporabo brezžične tehnologije LORA
David Zidar, David Nedeljković
Diplomsko delo
Oznake: pametne vtičnice;LoRaWAN;LoRa;omrežni prehodi;internetni strežniki;prožnost;klimatske naprave;elektroenergetska omrežja;visokošolski strokovni študij;Aplikativna elektrotehnika;diplomske naloge;
Prožnost elektroenergetskih omrežij se ukvarja s prilagajanjem proizvodnje ter odjema električne energije. V času prehoda na proizvodnjo električne energije z obnovljivimi viri bo področje prožnosti najverjetneje aktualno tudi pri nizkonapetostnih odjemalcih električne energije – gospodinjstvih. Dol ...
Leto: 2022 Vir: Fakulteta za elektrotehniko (UL FE)
Spremljanje pokazateljev fiziološkega stanja vodnih osličkov iz jamskega in površinskega okolja
David Škufca, Primož Zidar, Primož Zidar, Anita Jemec, Anita Jemec, Kristina Sepčić, Kristina Sepčić, Simona Prevorčnik
Magistrsko delo
Oznake: vodni osliček;biomarkerji;monitoring;jame;površinski vodotoki;
Spremljanje pokazateljev fiziološkega stanja vodnih osličkov iz jamskega in površinskega okolja
Leto: 2016 Vir: Biotehniška fakulteta (UL BF)
Pathology of fibrosis in Crohn's disease-contribution to understanding its pathogenesis
Nina Zidar, Cord Langner, Miha Jerala, Emanuela Boštjančič, David Drobne, Aleš Tomažič
Izvirni znanstveni članek
Oznake: Crohn's disease;fibrosis;stenosis;pathology;pathogenesis;
Background: Despite significant progress in the research of fibrosis in various organs, fibrosis remains a poorly understood complication of Crohn's disease (CD). We analyzed pathologic features of fibrosis and inflammation in CD and compared them with the normal bowel, aiming to clarify whether fib ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Razvoj novih N-fenilpirolamidov kot zaviralcev DNA-giraze in topoizomeraze IV
Davide Benedetto Tiz, Nace Zidar, Danijel Kikelj
Doktorska disertacija
Oznake:
Odkritje penicilina Alexandra Fleminga leta 1928 predstavlja enega izmed najpomembnejših dosežkov v sodobnem zdravljenju infekcijskih bolezni. V naslednjih desetletjih je temu odkritju sledilo odkritje številnih drugih razredov antibiotikov. Množična uporaba antibiotikov pa je privedla do tega, da s ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Action of clathrodin and analogues on voltage-gated sodium channels
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David J. Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Izvirni znanstveni članek
Oznake: oroidin;hymenidin;clathrodin;voltage-gated sodium channels;sodium channel modulator;sponge;
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could representan interesting lead compound. Therefore, clathrodin was reinvestigated for its ...
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
Exploring the 5-substituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens
Maša Sterle, Martina Durcik, Clare E. M. Stevenson, Sara R. Henderson, Petra Eva Szili, Marton Czikkely, David M. Lawson, Danijel Kikelj, Nace Zidar, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Andrej Emanuel Cotman, Anamarija Zega
Izvirni znanstveni članek
Oznake: inhibitorji;organske kisline;proteini;bacteria;genetics;inhibitors;organic acids;peptides;proteins;
We present a new series of 2-aminobenzothiazole-based DNA gyrase B inhibitors with promising activity against ESKAPE bacterial pathogens. Based on the binding information extracted from the cocrystal structure of DNA gyrase B inhibitor A, in complex with Escherichia coli GyrB24, we expanded the chem ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Challenges and solutions in early detection, rapid response and communication about potential invasive alien species in forests
Maarten De Groot, Richard O'Hanlon, Erin Bullas-Appleton, György Csóka, Ágnes Csíszár, Massimo Faccoli, Eugenio Gervasini, Natalia Kirichenko, Márton Korda, Aleksander Marinšek, Nikki Robinson, Craig Shuttleworth, Jon Sweeney, Elena Tricarico, Laura Verbrugge, David Williams, Simon Zidar, Jana Kus Veenvliet
Pregledni znanstveni članek
Oznake: sistem zgodnjega opozarjanja;zdravstveno varstvo rastlin;Geosmithia morbida;EU;tujerodne vrste;early warning system;plant health legislation;EU IAS legislation;alien species;Emerald ash borer;American pokeweed;Grey squirrel;rapid response system;
Invasive alien species (IAS) are an important threat to forests. One of the best ways to manage potential IAS is through early detection and rapid response (EDRR) strategies. However, when dealing with IAS in forests, EU regulations are divided between phytosanitary regulations and IAS regulations. ...
Leto: 2020 Vir: Repozitorij Univerze v Ljubljani (RUL)
Discovery and Hit-to-Lead Optimization of Benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin-Mašič, Tihomir Tomašić, Danijel Kikelj
Izvirni znanstveni članek
Oznake: antibacterial activity;bacteria;genetics;inhibitors;solubility;
We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 27, featuring a 10-fold improved aqueous solubility ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Nace Zidar, Alessia Onali, Peter Peršolja, Davide Benedetto Tiz, Jaka Dernovšek, Žiga Skok, Martina Durcik, Andrej Emanuel Cotman, Martina Hrast, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Danijel Kikelj
Izvirni znanstveni članek
Oznake: antibacterial;DNA gyrase;GyrB;inhibitor;N-phenylpyrrolamide;ParE;topoisomerase IV;
In this work, we describe an improved series of N-phenylpyrrolamide inhibitors that exhibit potent activity against DNA gyrase and are highly effective against high-priority gram-positive bacteria. The most potent compounds show low nanomolar IC50 values against Escherichia coli DNA gyrase, and in a ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
Andrej Emanuel Cotman, Federica Fulgheri, Martina Piga, Peter Peršolja, Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Maša Sterle, Jaka Dernovšek, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Danijel Kikelj, Nace Zidar
Izvirni znanstveni članek
Oznake: N-fenilpirolamidni inhibitorji;bakterijske DNA giraze;sinteza spojin;antibakterijsko delovanje;
This study presents the discovery of a new series of N-phenylpyrrolamide inhibitors of bacterial DNA gyrase with improved antibacterial activity. The most potent inhibitors had low nanomolar IC50 values against Escherichia coli DNA gyrase (IC50; 2–20 nM) and E. coli topoisomerase IV (22i, IC50 = 143 ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 10
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