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Št. zadetkov: 6
Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos
Robert Frangež, Evelyne Benoit
Izvirni znanstveni članek
Oznake: chlormephos;organophosphorus pesticide;chronical oral administration;mouse sciatic nerve;diphasic compound action potential;ex vivo electrophysiology;
The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals ...
Leto: 2025 Vir: Veterinarska fakulteta (UL VF)
Ostreolysin A/pleurotolysin B and equinatoxins
Robert Frangež, Dušan Šuput, Jordi Molgó, Evelyne Benoit
Pregledni znanstveni članek
Oznake: ostreolysin A/pleurotolysin B;equinatoxins;pore-forming proteins;biological effects;pore forming cytotoxic proteins;relative biological effectiveness;
Acidic ostreolysin A/pleurotolysin B (OlyA/PlyB, formerly known as ostreolysin (Oly), and basic 20 kDa equinatoxins (EqTs) are cytolytic proteins isolated from the edible mushroom Pleurotus ostreatus and the sea anemone Actinia equina, respectively. Both toxins, although from different sources, shar ...
Leto: 2017 Vir: Veterinarska fakulteta (UL VF)
Equinatoxin II
Evelyne Benoit, Robert Frangež, Gilles Ouanounou, Frédéric A. Meunier, Dušan Šuput, Jordi Molgó
Izvirni znanstveni članek
Oznake: axonal swelling;cationic pore-forming peptide;confocal laser scanning microscopy;equinatoxin II;ionic mechanisms;myelinated nerve fiber;
This study was performed to elucidate the mechanism underpinning the nodal swelling induced by equinatoxin II (EqtII), a cation-selective pore-forming toxin derived from the sea anemone Actinia equina. Experiments were conducted using frog myelinated nerve fibers as a model system. Application of Eq ...
Leto: 2026 Vir: Veterinarska fakulteta (UL VF)
Novel short-acting non-depolarizing muscle relaxants derived from galantamine
Robert Frangež, Julien Rouleau, Jordi Molgó, Monika C. Žužek, Evelyne Benoit, Catherine Guillou
Izvirni znanstveni članek
Oznake: derivati ​​galantamina;mišični relaksanti;nikotinski acetilholinski receptorji;nevromuskularni prenos pri glodalcih;elektrofiziologija;kardiovaskularni sistem;serumski elektroliti;galantamine derivatives;muscle relaxants;nicotinic acetylcholine receptors;rodent neuromuscular transmission;electrophysiology;cardiovascular system;serum electrolytes;
This study evaluated two novel galantamine-derived compounds, DR-976 and compound 15, as potential short-acting, non-depolarizing muscle relaxants. The aim was to introduce a long carbon chain bearing a quaternary ammonium group on the galantamine scaffold, in order to redirect its pharmacological p ...
Leto: 2026 Vir: Veterinarska fakulteta (UL VF)
Structural and functional characterization of an organometallic ruthenium complex as a potential myorelaxant drug
Tomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Jakob Kljun, Iztok Turel, Evelyne Benoit, Robert Frangež
Izvirni znanstveni članek
Oznake: organoruthenium nitrophenanthroline complex;acetylcholinesterase;butyrylcholinesterase;glutathione S-transferase;mouse neuromuscular system;ruthenium;muscle relaxation;physiology;glutathione transferase;
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylcholine receptors (nAChRs) and thus affect the neuromu ...
Leto: 2020 Vir: Veterinarska fakulteta (UL VF)
New insights into the effects of organometallic ruthenium complexes on nicotinic acetylcholine receptors
Tomaž Trobec, Nicolas Lamassiaude, Evelyne Benoit, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Iztok Turel, Rómulo Aráoz, Robert Frangež, Robert Frangež
Izvirni znanstveni članek
Oznake: organometallic ruthenium complexes;nicotinic acetylcholine receptors;nicotinic antagonists;electrophysiology;two-electrode voltage-clamp technique;
Nicotinic acetylcholine receptors (nAChRs) are expressed in excitable and non-excitable cells of the organism. Extensive studies suggest that nAChR ligands have therapeutic potential, notably for neurological and psychiatric disorders. Organometallic ruthenium complexes are known to inhibit several ...
Leto: 2024 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 6
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