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Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity
Mahmoud Abdellatif, Viktoria Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J Hofer, Moydul Islam, Julia Voglhuber, Simon Sedej
Izvirni znanstveni članek
Oznake: aging;autophagy;cardiomyopathies;insulin-like growth factor 1;mitochondria;mouse;phosphatidylinositol 3-kinases;
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to assess ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
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