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Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart
Mahmoud Abdellatif, Frank Madeo, Guido Kroemer, Simon Sedej
Kratki znanstveni prispevek
Oznake: heart failure;IGF1R;PI3K;human;insulin signaling;longevity;mitochondrial dysfunction;mouse;
Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-i ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 1
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